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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Antiviral effect of interferon lambda against West Nile virus
Antiviral research, v 83(1), pp 53-60
2009
PMID: 19501257
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Type III interferons (IFN), IFN-λ or IL-28/29, are new members of the IFN super-family. Except for using distinct receptors, type I and type III IFNs share the same major post receptor signaling components to activate the transcription of a similar set of IFN-stimulated genes (ISGs). To examine the antiviral effects of the new type IFNs against West Nile virus (WNV), we compared the antiviral effects of IFN-α and IFN-λ on WNV virus-like particle (VLP) infection and replicon replication in Huh7.5 and Hela cells. The results revealed that (i) both types of IFNs could efficiently prevent the WNV infection, but IFN-α demonstrated a stronger antiviral efficacy; (ii) WNV genome replication in VLP-infected cells and replicon-containing cell lines could only be inhibited by IFN-α, but not IFN-λ; (iii) in agreement with the observed antiviral effects, only IFN-λ-induced activation of JAK-STAT signaling pathway and induction of ISG expression were completely inhibited in WNV replicon-containing cell lines, but IFN-α signal transduction was either unaffected or only partially inhibited in Huh7.5 or Hela cells by the virus. Hence, the differential inhibition of WNV on IFN-α and IFN-λ signal transduction implies that the receptors of the two types of IFNs, but not the common post receptor signaling components, could be selectively targeted either directly by WNV nonstructural proteins or indirectly by the cellular responses induced by the virus infection to inhibit the signal transduction of the cytokines.
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Details
- Title
- Antiviral effect of interferon lambda against West Nile virus
- Creators
- Dongling Ma - Drexel UniversityDong Jiang - Drexel UniversityMin Qing - Wadsworth CenterJessica M. Weidner - Drexel UniversityXiaowang Qu - Drexel UniversityHaitao Guo - Drexel UniversityJinhong Chang - Drexel UniversityBaohua Gu - Drexel UniversityPei-Yong Shi - Wadsworth CenterTimothy M. Block - Drexel UniversityJu-Tao Guo - Drexel University
- Publication Details
- Antiviral research, v 83(1), pp 53-60
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000267480100007
- Scopus ID
- 2-s2.0-67349199176
- Other Identifier
- 991019168467204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy
- Virology