Journal article
Apigenin, a Natural Flavonoid, Attenuates EAE Severity Through the Modulation of Dendritic Cell and Other Immune Cell Functions
Journal of neuroimmune pharmacology, v 11(1)
Mar 2016
PMID: 26040501
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Apigenin, a natural flavonoid, found in several plants, fruits, vegetables, herbs, and spices, is known to have anti-oxidant and anti-inflammatory properties that are evident in the use of these substances for centuries as medicinal approaches to treat asthma, insomnia, Parkinson's disease, neuralgia, and shingles. However, there is a considerable dearth of information regarding its effect on immune cells, especially dendritic cells (DC) that maintain the critical balance between an immunogenic and tolerogenic immune response, in an immunospecialized location like the central nervous system (CNS). In this paper we looked at the anti-inflammatory properties of Apigenin in restoration of immune function and the resultant decrease in neuroinflammation. In vivo, a significant reduction in severity of experimental autoimmune encephalomyelitis (EAE) progression and relapse was observed in C57BL/6 (progressive) and SJL/J (relapse-remitting) mouse models of multiple sclerosis upon treatment with Apigenin. Apigenin treated EAE mice show decreased expression of α4 integrin and CLEC12A on splenic DCs and an increased retention of immune cells in the periphery compared to untreated EAE mice. This correlated consequently with immunohistochemistry findings of decreased immune cell infiltration and reduced demyelination in the CNS. These results indicate a protective role of Apigenin against the neurodegenerative effects resulting from the entry of DC stimulated pathogenic T cells into the CNS thus implicating a potential therapy for neuroinflammatory disease.
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Details
- Title
- Apigenin, a Natural Flavonoid, Attenuates EAE Severity Through the Modulation of Dendritic Cell and Other Immune Cell Functions
- Creators
- Rashida Ginwala - Department of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19129, USAEmily McTish - Department of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19129, USAChander Raman - Division of Clinical Immunology and Rheumatology, University of Alabama School of Medicine, Birmingham, AB, USANarendra Singh - Department of Pathology, Microbiology and Immunology, University of South Carolina, Columbia, SC, USAMitzi Nagarkatti - Department of Pathology, Microbiology and Immunology, University of South Carolina, Columbia, SC, USAPrakash Nagarkatti - Department of Pathology, Microbiology and Immunology, University of South Carolina, Columbia, SC, USADivya Sagar - Department of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19129, USAPooja Jain - Department of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19129, USA. pjain@drexelmed.eduZafar K Khan - Department of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA, 19129, USA. zkhan@drexelmed.edu
- Publication Details
- Journal of neuroimmune pharmacology, v 11(1)
- Publisher
- Springer Nature; United States
- Grant note
- R01 AT006888 / NCCIH NIH HHS P01 AT003961 / NCCIH NIH HHS R01 NS097147 / NINDS NIH HHS R56 AI077414 / NIAID NIH HHS P20 GM103641 / NIGMS NIH HHS R01 DA016545 / NIDA NIH HHS R01CA054559 / NCI NIH HHS R56AI077414 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000369519400004
- Scopus ID
- 2-s2.0-84957441814
- Other Identifier
- 991014877806804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy