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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Appendicular lean mass and mortality among prefrail and frail older adults
The Journal of nutrition, health & aging, v 21(3), pp 342-345
2017
PMID: 28244576
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective
Prefrail and frail older adults are a heterogeneous population. The measurement of appendicular lean mass (ALM) may distinguish those at higher versus lower risk of poor outcomes. We examined the relationship between ALM and mortality among prefrail and frail older adults.
Design
This was a population-based cohort study.
Setting
The Third National Health and Nutrition Survey (NHANES III; 1988-1994).
Participants
Older adults (age ≥65 years) with pre-frailty or frailty defined using the Fried criteria.
Measurements
ALM was quantified using bioimpedance analysis. Multivariable-adjusted Cox regression analysis examined the relationship between ALM and mortality. Logistic regression analysis was used to determine if ALM added to age and sex improved the predictive discrimination of five-year and ten-year mortality.
Results
At baseline, the average age was 74.9 years, 66.7% were female, 86.3% and 13.7% were prefrail and frail, respectively. The mean ALM was 18.9 kg [standard deviation (SD): 5.5]. During a median 8.9 years of follow-up, 1,307 of 1,487 study participants died (87.9%). Higher ALM was associated with a lower risk of mortality. In a multivariable-adjusted regression model that accounted for demographic, behavioral, clinical, physical function, and frailty characteristics, each SD increase in ALM was associated with an 50% lower risk of mortality [Hazard Ratio: 0.50 (95% CI: 0.27-0.92); P=0.026]. The addition of ALM to age and sex improved the predictive discrimination of five-year (P=0.027) and ten-year (P=0.016) mortality.
Conclusion
ALM distinguishes the risk of mortality among prefrail and frail older adults. Additional research examining ALM as a therapeutic target is warranted.
Metrics
Details
- Title
- Appendicular lean mass and mortality among prefrail and frail older adults
- Creators
- Justin C. Brown - University of PennsylvaniaM. O. Harhay - University of PennsylvaniaM. N. Harhay - Drexel University
- Publication Details
- The Journal of nutrition, health & aging, v 21(3), pp 342-345
- Publisher
- Springer Paris
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000396203100017
- Scopus ID
- 2-s2.0-85014424385
- Other Identifier
- 991019335319904721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Nutrition & Dietetics