Journal article
Applications of dynamic functional connectivity to pain and its modulation
Pain reports, v 4(4), pp e752-e752
01 Jul 2019
PMID: 31579848
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Since early work attempting to characterize the brain's role in pain, it has been clear that pain is not generated by a specific brain region, but rather by coordinated activity across a network of brain regions, the "neuromatrix." The advent of noninvasive whole-brain neuroimaging, including functional magnetic resonance imaging, has provided insight on coordinated activity in the pain neuromatrix and how correlations in activity between regions, referred to as "functional connectivity," contribute to pain and its modulation. Initial functional connectivity investigations assumed interregion connectivity remained stable over time, and measured variability across individuals. However, new dynamic functional connectivity (dFC) methods allow researchers to measure how connectivity changes over time within individuals, permitting insights on the dynamic reorganization of the pain neuromatrix in humans. We review how dFC methods have been applied to pain, and insights afforded on how brain connectivity varies across time, either spontaneously or as a function of psychological states, cognitive demands, or the external environment. Specifically, we review psychophysiological interaction, dynamic causal modeling, state-based dynamic community structure, and sliding-window analyses and their use in human functional neuroimaging of acute pain, chronic pain, and pain modulation. We also discuss promising uses of dFC analyses for the investigation of chronic pain conditions and predicting pain treatment efficacy and the relationship between state- and trait-based pain measures. Throughout this review, we provide information regarding the advantages and shortcomings of each approach, and highlight potential future applications of these methodologies for better understanding the brain processes associated with pain.
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Details
- Title
- Applications of dynamic functional connectivity to pain and its modulation
- Creators
- Elizabeth A. Necka - National Center for Complementary and Integrative HealthIn-Seon Lee - National Center for Complementary and Integrative HealthAaron Kucyi - Stanford UniversityJoshua C. Cheng - Stony Brook UniversityQingbao Yu - National Center for Complementary and Integrative HealthLauren Y. Atlas - National Institute on Drug Abuse
- Publication Details
- Pain reports, v 4(4), pp e752-e752
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000693774800007
- Scopus ID
- 2-s2.0-85083914126
- Other Identifier
- 991021448178904721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences