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Approximating the Spanning Star Forest Problem and Its Application to Genomic Sequence Alignment
Journal article   Peer reviewed

Approximating the Spanning Star Forest Problem and Its Application to Genomic Sequence Alignment

C. Thach Nguyen, Jian Shen, Minmei Hou, Li Sheng, Webb Miller and Louxin Zhang
SIAM journal on computing, v 38(3), pp 946-962
01 Jan 2008

Abstract

Algorithms Applied mathematics Approximation Computer science Forests Genes Genomics Graphs
This paper studies the algorithmic issues of the spanning star forest problem. We prove the following results: (1) There is a polynomial-time approximation scheme for planar graphs; (2) there is a polynomial-time $\frac{3}{5}$-approximation algorithm for graphs; (3) it is NP-hard to approximate the problem within ratio $\frac{259}{260} + \epsilon$ for graphs; (4) there is a linear-time algorithm to compute the maximum star forest of a weighted tree; (5) there is a polynomial-time $\frac{1}{2}$-approximation algorithm for weighted graphs. We also show how to apply this spanning star forest model to aligning multiple genomic sequences over a tandem duplication region.

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Domestic collaboration
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Web of Science research areas
Computer Science, Theory & Methods
Mathematics, Applied
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