Journal article
Aptamers capable of simultaneously identifying multiple targets and corresponding applications in medical diagnosis-A review
International journal of biological macromolecules, v 311(3), 143666
30 Apr 2025
PMID: 40316072
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aptamers, a unique class of nucleic acid sequences recognized for their specific binding capabilities, have found widespread application in biomedical field. While traditional aptamers are typically designed to target a single molecule recognition, recent attention has been directed towards multifunctional aptamers capable of simultaneously identifying multiple targets. In this review, the latest advancements in multifunctional aptamers and their applications in medical diagnosis are presented for the first time. This review focuses on the following essential aspects, including methods employed for developing multifunctional aptamers, detailed characteristics of these aptamers, practical applications across diverse diagnostic scenarios, and in-depth discussions on critical aspects of their design and utility. To conclude, future perspectives are provided to drive further development and broader application of multifunctional aptamers in the biomedical domain.
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Details
- Title
- Aptamers capable of simultaneously identifying multiple targets and corresponding applications in medical diagnosis-A review
- Creators
- Ling Li - Beijing University of Chemical TechnologyMenglei Li - Beijing University of Chemical TechnologyYinghua Qiu - Drexel UniversitySai Wang - Ocean University of ChinaYiyang Dong - Beijing University of Chemical Technology
- Publication Details
- International journal of biological macromolecules, v 311(3), 143666
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- Fundamental Research Funds for the Central Universities: 202341012 National Natural Science Foundation of China: 32102120
This work was supported by the Fundamental Research Funds for the Central Universities (202341012) and the National Natural Science Foundation of China (32102120) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:001510324200001
- Scopus ID
- 2-s2.0-105004264541
- Other Identifier
- 991022050851804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Applied
- Polymer Science