Journal article
Are Empirically-Derived Subtypes of Mild Cognitive Impairment Consistent with Conventional Subtypes?
Journal of the International Neuropsychological Society, v 19(6), pp 635-645
01 Jul 2013
PMID: 23552486
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Given the importance of identifying dementia prodromes for future treatment efforts, we examined two methods of diagnosing mild cognitive impairment (MCI) and determined whether empirically-derived MCI subtypes of these diagnostic methods were consistent with one another as well as with conventional MCI subtypes (i.e., amnestic, non-amnestic, single-domain, multi-domain). Participants were diagnosed with MCI using either conventional Petersen/Winblad criteria (n = 134; >1.5 SDs below normal on one test within a cognitive domain) or comprehensive neuropsychological criteria developed by Jak et al. (2009) (n = 80; >1 SD below normal on two tests within a domain), and the resulting samples were examined via hierarchical cluster and discriminant function analyses. Results showed that neuropsychological profiles varied depending on the criteria used to define MCI. Both criteria revealed an Amnestic subtype, consistent with prodromal Alzheimer's disease (AD), and a Mixed subtype that may capture individuals in advanced stages of MCI. The comprehensive criteria uniquely yielded Dysexecutive and Visuospatial subtypes, whereas the conventional criteria produced a subtype that performed within normal limits, suggesting its susceptibility to false positive diagnostic errors. Whether these empirically-derived MCI subtypes correspond to dissociable neuropathologic substrates and represent reliable prodromes of dementia will require additional follow-up. (JINS, 2013, 19, 1–11)
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Details
- Title
- Are Empirically-Derived Subtypes of Mild Cognitive Impairment Consistent with Conventional Subtypes?
- Creators
- Lindsay R. Clark - San Diego State UniversityLisa Delano-Wood - 2Department of Veterans Affairs San Diego Healthcare System, San Diego, CaliforniaDavid J. Libon - Drexel UniversityCarrie R. McDonald - University of California San DiegoDaniel A. Nation - VA San Diego Healthcare SystemKatherine J. Bangen - University of California San DiegoAmy J. Jak - VA San Diego Healthcare SystemRhoda Au - Boston UniversityDavid P. Salmon - University of California San DiegoMark W. Bondi - VA San Diego Healthcare System
- Publication Details
- Journal of the International Neuropsychological Society, v 19(6), pp 635-645
- Publisher
- Cambridge University Press
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000320869700002
- Scopus ID
- 2-s2.0-84880467669
- Other Identifier
- 991021901314104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Psychiatry
- Psychology