Journal article
Are carfentanil and acrylfentanyl naloxone resistant?
Frontiers in psychiatry, v 15
20 Feb 2024
PMID: 38445085
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The rapid rise in deaths since 2012 due to opioid poisoning is correlated with the proliferation of potent synthetic opioid agonists such as fentanyl, acrylfentanyl, and carfentanil. The efficacy of frontline antidotes such as naloxone in reversing such poisoning events has been questioned, and the possibility of naloxone-resistant synthetic opioids has been raised. In this manuscript, we applied in vitro techniques to establish the median effective inhibitory concentrations for fentanyl, acrylfentanyl, and carfentanil and subsequently evaluate naloxone's ability to reverse agonist-receptor interactions.
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Details
- Title
- Are carfentanil and acrylfentanyl naloxone resistant?
- Creators
- Michael G. Feasel - Defense Advanced Research Projects AgencyTheodore S. Moran - United States ArmyBoyle C. Cheng - Allegheny Hlth Network, Neurosci Inst, Pittsburgh, PA 15224 USASaadyah Averick - Allegheny Health Network
- Publication Details
- Frontiers in psychiatry, v 15
- Publisher
- Frontiers Media Sa
- Number of pages
- 6
- Grant note
- National Institute on Drug Abuse10.13039/100000026
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery; Neurosurgery
- Web of Science ID
- WOS:001175673500001
- Scopus ID
- 2-s2.0-85186546341
- Other Identifier
- 991021930321004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry