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Journal article
Are polymorphisms in metabolism protective or a risk for reduced white blood cell counts in a Chinese population with low occupational benzene exposures?
International journal of occupational and environmental health, v 21(3), pp 232-240
01 Sep 2015
PMID: 26179485
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background:
Genetic variations in metabolic enzyme genes may enhance hematotoxicity in benzene-exposed populations.
Objective:
To investigate the association between polymorphisms of metabolism genes and white blood cells (WBCs).
Methods:
Three hundred and eighty-five benzene-exposed workers and 220 unexposed indoor workers were recruited in China. We explored the relationship between metabolic enzymes polymorphisms [glutathione S-transferase T1/M1 (GSTT1/M1) null, glutathione S-transferase P1 (GSTP1)rs1695, Cytochrome P450 2E1 (CYP2E1) rs3813867, rs2031920, rs6413432, microsomal epoxide hydrolase (mEH) rs1051740, rs2234922] by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis and WBC.
Results:
The exposed group had lower WBC counts (P<0·001) than the unexposed group. Increased susceptibility to hematotoxicity, as evidenced by lower WBC counts, was found in workers with null-GSTT1 (P = 0·045), null-GSTM1 (P = 0·030), rs2031920 (P = 0·020), and rs3813867 (P = 0·014) genotypes. White blood cell counts were also lower in workers with null-GSTT1 and null-GSTM after adjusting for age, gender, smoking, and alcohol consumption.
Conclusion:
Null-GSTT1 and null-GSTM1 genotypes and Cytochrome P4502E1 (CYP2E1: rs2031920, rs3813867) may support the hematotoxicity of benzene-exposed workers in China, and we can make use of it to select susceptible population.
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Details
- Title
- Are polymorphisms in metabolism protective or a risk for reduced white blood cell counts in a Chinese population with low occupational benzene exposures?
- Creators
- Ling-li Ye - Wenzhou City People's HospitalGuang-hui Zhang - Fudan UniversityJing-wen Huang - Fudan UniversityYong Li - Fudan UniversityGuo-qiao Zheng - Fudan UniversityDe-ting Zhang - Wenzhou City People's HospitalLi-fang Zhou - Fudan UniversityXi-dan Tao - Wenzhou Institute of Technology Testing & CalibrationJing Zhang - Fudan UniversityYun-jie Ye - Fudan UniversityPin Sun - Fudan UniversityArthur Frank - Drexel UniversityZhao-lin Xia - Fudan University
- Publication Details
- International journal of occupational and environmental health, v 21(3), pp 232-240
- Publisher
- Taylor & Francis
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000361631500007
- Scopus ID
- 2-s2.0-84941621408
- Other Identifier
- 991019168246004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health