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Arginine or nitrate enhances antibiotic susceptibility of Pseudomonas aeruginosa in biofilms
Journal article   Open access   Peer reviewed

Arginine or nitrate enhances antibiotic susceptibility of Pseudomonas aeruginosa in biofilms

Giorgia Borriello, Lee Richards, Garth D Ehrlich and Philip S Stewart
Antimicrobial agents and chemotherapy, v 50(1), pp 382-384
Jan 2006
PMID: 16377718
url
https://doi.org/10.1128/AAC.50.1.382-384.2006View
Published, Version of Record (VoR) Open

Abstract

Anaerobiosis Biofilms - drug effects Drug Synergism Pseudomonas aeruginosa - isolation & purification Pseudomonas aeruginosa - growth & development Tobramycin - pharmacology Nitrates - pharmacology Tobramycin - administration & dosage Anti-Bacterial Agents - pharmacology Pseudomonas aeruginosa - drug effects Arginine - drug effects Pseudomonas Infections - microbiology
Arginine enhanced the killing of Pseudomonas aeruginosa by ciprofloxacin and tobramycin under anaerobic, but not aerobic, growth conditions. Arginine or nitrate also enhanced the killing by these antibiotics in mature biofilms, reducing viable cell counts by a factor of 10 to 100 beyond that achieved by antibiotics alone.

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Web of Science research areas
Microbiology
Pharmacology & Pharmacy
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