Arterial Stiffness and Wave Reflection 1 Year After a Pregnancy Complicated by Hypertension

Deborah B. Ehrenthal; Neal D. Goldstein; Pan Wu; Stephanie Rogers; Raymond R. Townsend; David G. Edwards

doi:10.1111/jch.12398

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Arterial Stiffness and Wave Reflection 1 Year After a Pregnancy Complicated by Hypertension

Journal article

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Arterial Stiffness and Wave Reflection 1 Year After a Pregnancy Complicated by Hypertension

Deborah B. Ehrenthal, Neal D. Goldstein, Pan Wu, Stephanie Rogers, Raymond R. Townsend and David G. Edwards

The journal of clinical hypertension (Greenwich, Conn.), v 16(10), pp 695-699

13 Aug 2014

DOI: https://doi.org/10.1111/jch.12398

PMID: 25116457

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Abstract

Original Paper

Hypertensive disorders of pregnancy ( HDP ) are associated with cardiovascular disease ( CVD ) later in life. The authors investigated the association of HDP with blood pressure ( BP ) and arterial stiffness 1‐year postpartum. Seventy‐four participants, 33 with an HDP and 41 with uncomplicated pregnancies, were examined using applanation tonometry to measure BP , carotid‐femoral pulse wave velocity (cf PWV ), and augmentation index ( AI x). On average, women with HDP had a 9 mm higher systolic BP ( P <.01), 0.8 m/s faster cf PWV ( P =.09), and 5.4% greater AI x ( P =.09) at the 1‐year examination. After adjustment for covariates, there was no significant difference in cf PWV between groups, while a 7.3% greater AI x ( P <.05) remained. These findings suggest that reduced endothelial function may be detected 1 year after HDP . Large prospective studies are needed to further understand the contribution of arterial stiffness and endothelial dysfunction in the evolution of CVD after these complicated pregnancies.

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Details

Title: Arterial Stiffness and Wave Reflection 1 Year After a Pregnancy Complicated by Hypertension
Creators: Deborah B. Ehrenthal - Christiana Care Health System
Neal D. Goldstein - Christiana Care Health System
Pan Wu - Christiana Care Health System
Stephanie Rogers - Christiana Care Health System
Raymond R. Townsend - University of Pennsylvania
David G. Edwards - University of Delaware
Publication Details: The journal of clinical hypertension (Greenwich, Conn.), v 16(10), pp 695-699
Publisher: John Wiley and Sons Inc
Grant note: National Institutes of Health to Deborah Ehrenthal 8 P20 GM103446‐13 / National Institute of General Medical Sciences—NIGMS
Resource Type: Journal article
Language: English
Academic Unit: Epidemiology and Biostatistics
Web of Science ID: WOS:000344850200001
Scopus ID: 2-s2.0-84907879603
Other Identifier: 991020100074404721

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Collaboration types: Domestic collaboration
Web of Science research areas: Peripheral Vascular Disease