Journal article
Aspergillus fumigatus CYP51 sequence: potential basis for fluconazole resistance
Medical mycology (Oxford), v 39(3)
Jun 2001
PMID: 11446535
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have cloned and sequenced the Aspergillus fumigatus CYP51 gene which encodes the target of azole antifungal agents, namely cytochrome P450 sterol 14alpha-demethylase. Since A. fumigatus is intrinsically resistant to the widely used azole fluconazole, we compared its predicted CYP51 sequence to the CYP51 sequences from fluconazole-susceptible and resistant Candida albicans. This analysis generated specific hypotheses regarding the basis for A. fumigatus fluconazole resistance; in particular, A. fumigatus residue Ile301 corresponds to C. albicans residue Thr315 which is mutated to Ala in resistant strains and is proposed to hydrogen bond with the sterol substrate.
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Details
- Title
- Aspergillus fumigatus CYP51 sequence: potential basis for fluconazole resistance
- Creators
- T D Edlind - MCP Hahnemann University, Philadelphia, Pennsylvania 19129, USA. edlind@drexel.eduK W HenryK A MeteraS K Katiyar
- Publication Details
- Medical mycology (Oxford), v 39(3)
- Publisher
- Taylor and Francis; England
- Grant note
- AI32433 / NIAID NIH HHS AI46768 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000169781300010
- Scopus ID
- 2-s2.0-0034955638
- Other Identifier
- 991014878002804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Infectious Diseases
- Mycology
- Veterinary Sciences