Journal article
Assessment of interstitial lung disease among black rheumatoid arthritis patients
Clinical rheumatology, v 38(12), pp 3413-3424
Dec 2019
PMID: 31471819
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Conflicting reports exist regarding the racial and the gender distribution of rheumatoid arthritis-related interstitial lung disease (RA-ILD). In a major population study of predominately Whites, RA-ILD was reported mainly among smoker middle-aged men. However, recent data suggest that the disease is that of elderly women. Our study aimed to assess the prevalence and identify the gender differences and clinical characteristics of RA-ILD in a predominantly Black population.
Cross-sectional analysis of data obtained from the records of 1142 patients with RA diagnosis by ICD codes of which 503 cases met the inclusion criteria for the study. Eighty-six patients had chronic respiratory symptoms of cough and dyspnea and were further assessed by our multidisciplinary group of investigators. Thirty-two subjects with an established diagnosis of rheumatoid arthritis met the diagnostic criteria for interstitial lung disease.
Of the 32 patients with RA-ILD, mean age was 62.6 ± 2.2 (± SEM), 93.7% were females, and 89% Blacks with a BMI = 29.2 (Kg/m). Usual interstitial pneumonia (UIP) was found in 24/32 (75%) of the cases. Seventy-two percent of the RA-ILD patient had seropositive RA. Smoking history was reported in 31.3% of the cohort, gastroesophageal reflux disease (GERD) in 32.3%, and cardiovascular disease (CVD) risk factors in 65.6%.
Our study indicates RA-ILD among Blacks is predominantly a disease of elderly females with higher rates of GERD and CVD risk factors. Further studies are needed to identify the pathogenetic differences accounting for the gender distribution of RA-ILD among Black and White populations.
Key Points
• First study to assess ILD among predominantly Black RA patients.
• The prevalence of RA-associated ILD was 6.36%, affecting mostly women in their sixth decade with seropositive disease.
• COPD was the most common airway disease among non-RA-ILD Black population.
• GERD was found in approximately one-third of patients with RA-associated ILD versus one-fifth of those RA patients without any lung disease.
Metrics
Details
- Title
- Assessment of interstitial lung disease among black rheumatoid arthritis patients
- Creators
- Isabel M McFarlane - State University of New YorkSu Yien Zhaz - State University of New YorkManjeet S Bhamra - State University of New YorkAaliya Burza - State University of New YorkSrinivas Kolla - State University of New YorkMilena Rodriguez Alvarez - State University of New YorkKristaq Koci - State University of New YorkNicholas Taklalsingh - State University of New YorkJoshy Pathiparampil - State University of New YorkLatoya Freeman - State University of New YorkIan Kaplan - State University of New YorkNaureen Kabani - State University of New YorkDavid J Ozeri - State University of New YorkElsie Watler - State University of New YorkMosab Frefer - State University of New YorkVytas Vaitkus - State University of New YorkKeron Matthew - State University of New YorkFray Arroyo-Mercado - State University of New YorkHelen Lyo - State University of New YorkTomasz Zrodlowski - SUNY Downstate Health Sciences UniversityAleksander Feoktistov - State University of New YorkRandolph Sanchez - Hahnemann University HospitalCristina Sorrento - State University of New YorkFaisal Soliman - State University of New YorkFelix Reyes Valdez - Albert Einstein College of MedicineVeena Dronamraju - State University of New YorkMichael Trevisonno - State University of New YorkChriston Grant - State University of New YorkGuerrier Clerger - State University of New YorkKhabbab Amin - State University of New YorkMakeda Dawkins - State University of New YorkJason Green - State University of New YorkJane Moon - State University of New YorkSamir Fahmy - State University of New YorkStephen Anthony Waite - State University of New York
- Publication Details
- Clinical rheumatology, v 38(12), pp 3413-3424
- Number of pages
- 12
- Grant note
- S21MD012474. / NIH HHS P20 MD006875 / NIMHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Rheumatology
- Web of Science ID
- WOS:000496697000010
- Scopus ID
- 2-s2.0-85072011072
- Other Identifier
- 991021860688604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology