Journal article
Assessment of lamellar level properties in mouse bone utilizing a novel spherical nanoindentation data analysis method
Journal of the mechanical behavior of biomedical materials, v 13, pp 102-117
Sep 2012
PMID: 22842281
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this work, we demonstrate the viability of using our recently developed data analysis procedures for spherical nanoindentation in conjunction with Raman spectroscopy for studying lamellar-level correlations between the local composition and local mechanical properties in mouse bone. Our methodologies allow us to convert the raw load-displacement datasets to much more meaningful indentation stress–strain curves that accurately capture the loading and unloading elastic moduli, the indentation yield points, as well as the post-yield characteristics in the tested samples. Using samples of two different inbred mouse strains, A/J and C57BL/6J (B6), we successfully demonstrate the correlations between the mechanical information obtained from spherical nanoindentation measurements to the local composition measured using Raman spectroscopy. In particular, we observe that a higher mineral-to-matrix ratio correlated well with a higher local modulus and yield strength in all samples. Thus, new bone regions exhibited lower moduli and yield strengths compared to more mature bone. The B6 mice were also found to exhibit lower modulus and yield strength values compared to the more mineralized A/J strain.
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Details
- Title
- Assessment of lamellar level properties in mouse bone utilizing a novel spherical nanoindentation data analysis method
- Creators
- Siddhartha Pathak - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USAShraddha J Vachhani - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USAKarl J Jepsen - Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48104, USAHaviva M Goldman - Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USASurya R Kalidindi - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA
- Publication Details
- Journal of the mechanical behavior of biomedical materials, v 13, pp 102-117
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000311469300011
- Scopus ID
- 2-s2.0-84864143362
- Other Identifier
- 991014878095504721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials