Files and links (2)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Assessment of occupational exposure to pesticides in a pooled analysis of agricultural cohorts within the AGRICOH consortium
Occupational and environmental medicine (London, England), v 73(6), pp 359-367
Jun 2016
PMID: 27009271
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundThis paper describes methods developed to assess occupational exposure to pesticide active ingredients and chemical groups, harmonised across cohort studies included in the first AGRICOH pooling project, focused on the risk of lymph-haematological malignancies.MethodsThree prospective agricultural cohort studies were included: US Agricultural Health Study (AHS), French Agriculture and Cancer Study (AGRICAN) and Cancer in the Norwegian Agricultural Population (CNAP). Self-reported pesticide use was collected in AHS. Crop-exposure matrices (CEMs) were developed for AGRICAN and CNAP. We explored the potential impact of these differences in exposure assessment by comparing a CEM approach estimating exposure in AHS with self-reported pesticide use.ResultsIn AHS, 99% of participants were considered exposed to pesticides, 68% in AGRICAN and 63% in CNAP. For all cohorts combined (n=316 270), prevalence of exposure ranged from 19% to 59% for 14 chemical groups examined, and from 13% to 46% for 33 active ingredients. Exposures were highly correlated within AGRICAN and CNAP where CEMs were applied; they were less correlated in AHS. Poor agreement was found between self-reported pesticide use and assigned exposure in AHS using a CEM approach resembling the assessment for AGRICAN (κ −0.00 to 0.33) and CNAP (κ −0.01 to 0.14).ConclusionsWe developed country-specific CEMs to assign occupational exposure to pesticides in cohorts lacking self-reported data on the use of specific pesticides. The different exposure assessment methods applied may overestimate or underestimate actual exposure prevalence, and additional work is needed to better estimate how far the exposure estimates deviate from reality.
Metrics
Details
- Title
- Assessment of occupational exposure to pesticides in a pooled analysis of agricultural cohorts within the AGRICOH consortium
- Creators
- Maartje Brouwer - Utrecht UniversityLeah Schinasi - Centre international de recherche sur le cancerLaura E Beane Freeman - Occupational and Environmental Epidemiology Branch, National Cancer Institute (NCI), Bethesda, Maryland, USAIsabelle Baldi - Bordeaux Population HealthPierre Lebailly - Cancers et PréventionsGilles Ferro - Centre international de recherche sur le cancerKarl-Christian Nordby - National Institute of Occupational HealthJoachim Schüz - Centre international de recherche sur le cancerMaria E Leon - Centre international de recherche sur le cancerHans Kromhout - Utrecht University
- Publication Details
- Occupational and environmental medicine (London, England), v 73(6), pp 359-367
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000376760500002
- Scopus ID
- 2-s2.0-84962808839
- Other Identifier
- 991020099051304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health