Journal article
Association Between Family Risk of Stroke and Myocardial Infarction With Prevalent Risk Factors and Coexisting Diseases
Stroke (1970), v 43(4), pp 974-979
01 Apr 2012
PMID: 22328552
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and Purpose-Familial transmission of stroke and myocardial infarction (MI) is partially mediated by transmission of cerebrovascular and cardiovascular risk factors. We examined relationships between family risk of stroke and MI with risk factors for these phenotypes.
Methods-A cross-sectional association between the stratified log-rank family score for stroke and MI with prevalent risk factors was assessed in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.
Results-Individuals in the fourth quartile of stratified log-rank family scores for stroke were more likely to have prevalent risk factors including hypertension (OR, 1.43; 95% CI, 1.30-1.58), left ventricular hypertrophy (OR, 1.42; 95% CI, 1.16-1.42), diabetes (OR, 1.26; 95% CI, 1.12-1.43), and atrial fibrillation (OR, 1.23; 95% CI, 1.03-1.45) compared with individuals in the first quartile. Likewise, individuals in the fourth quartile of stratified log-rank family scores for MI were more likely to have prevalent risk factors including hypertension (OR, 1.57; 95% CI, 1.27-1.94) and diabetes (OR, 1.29; 95% CI, 1.12-1.43) than the first quartile. In contrast to stroke, the family risk score for MI was associated with dyslipidemia (OR, 1.38; 95% CI, 1.23-1.55) and overweight/obesity (OR, 1.22; 95% CI, 1.10-1.37).
Conclusions-Family risk of stroke and MI is strongly associated with the majority of risk factors associated with each disease. Family history and genetic studies separating nonspecific contributions of intermediate phenotypes from specific contributions to the disease phenotype may lead to a more thorough understanding of transmission for these complex disorders. (Stroke. 2012;43:974-979.)
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Details
- Title
- Association Between Family Risk of Stroke and Myocardial Infarction With Prevalent Risk Factors and Coexisting Diseases
- Creators
- Richard E. Kennedy - University of Alabama at BirminghamGeorge Howard - Univ Alabama, Dept Biostat, Sch Publ Hlth, Birmingham, AL 35294 USARodney C. Go - Univ Alabama, Dept Epidemiol, Sch Publ Hlth, Birmingham, AL 35294 USAPeter M. Rothwell - Univ Oxford, Stroke Prevent Res Unit, Oxford, EnglandHemant K. Tiwari - Univ Alabama, Dept Biostat, Sch Publ Hlth, Birmingham, AL 35294 USARui Feng - University of AlabamaLeslie A. McClure - University of AlabamaRonald J. Prineas - Wake Forest Univ, Bowman Gray Sch Med, Div Publ Hlth Sci, Winston Salem, NC USAAmitava Banerjee - Univ Oxford, Stroke Prevent Res Unit, Oxford, EnglandDonna K. Arnett - Univ Alabama, Dept Epidemiol, Sch Publ Hlth, Birmingham, AL 35294 USA
- Publication Details
- Stroke (1970), v 43(4), pp 974-979
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- CL-2010-09-002 / National Institute for Health Research; National Institute for Health Research (NIHR) T32HL072757 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA NS 041588 / National Institute of Neurological Disorders and Stroke (NINDS); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) T32HL072757 / National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32HL072757 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01NS041588 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000302124200015
- Scopus ID
- 2-s2.0-84859433483
- Other Identifier
- 991019231637104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Peripheral Vascular Disease