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Journal article
Association Between Progranulin and β-Amyloid in Dementia With Lewy Bodies
American journal of Alzheimer's disease and other dementias, v 23(5), pp 488-493
Oct 2008
PMID: 18955727
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent studies demonstrated that progranulin plays an integral role in the pathogenesis of frontotemporal dementia. To begin to explore the role of progranulin in dementia with Lewy bodies, we investigate its association with pathologic proteins that characterize this disease. We assessed immunoreactivity for progranulin in medial temporal lobe structures of 12 cases of dementia with Lewy bodies. Similar data were collected for β-amyloid burden, and α-synuclein pathology. Blinded investigators used a 0-3—point scale to quantify progranulin burden. Double labeling for progranulin and β-amyloid was also performed. We were able to demonstrate progranulin immunoreactivity throughout the medial temporal lobe in all dementia with Lewy body cases. We identified a significant positive correlation (r = 0.606; P = .037) between β-amyloid burden and progranulin. There was no significant correlation between α-synuclein pathology or Braak stage and progranulin. Progranulin and β-amyloid co-localized in plaques in dementia with Lewy bodies, suggesting that there is likely a biological association between these 2 aggregated proteins.
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Details
- Title
- Association Between Progranulin and β-Amyloid in Dementia With Lewy Bodies
- Creators
- Gonzalo J. Revuelta - Drexel UniversityAndrea Rosso - Drexel UniversityCarol F. Lippa - Drexel University
- Publication Details
- American journal of Alzheimer's disease and other dementias, v 23(5), pp 488-493
- Publisher
- SAGE Publications
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000260312400011
- Scopus ID
- 2-s2.0-54049135189
- Other Identifier
- 991019312372204721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Geriatrics & Gerontology