Journal article
Association between GRIN2A promoter polymorphism and recovery from concussion
Brain injury, v 29(13-14), pp 1674-1681
06 Dec 2015
PMID: 26502998
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To determine genetic variability within the N-methyl-D-aspartate receptor 2A sub-unit (GRIN2A) gene promoter and its association with concussion recovery time. The hypothesis tested was that there would be a difference in allele and/or genotype distribution between two groups of athletes with normal and prolonged recovery.
Methods: DNA was extracted from saliva collected from a total of 87 athletes with a physician-diagnosed concussion. The (GT) variable number tandem repeats (VNTR) within the promoter region of GRIN2A was genotyped. The long (L) allele was an allele with ≥25 repeats and the short (S) allele was an allele with <25 repeats in the GT tract. Participants' recovery time was followed prospectively and was categorized as normal (≤60 days) or prolonged (>60 days).
Results: LL carriers were 6-times more likely to recover longer than 60 days following the concussive event (p = 0.0433) when compared to SS carriers. Additionally, L allele carriers were found more frequently in the prolonged recovery group (p = 0.048).
Conclusion: Determining genetic influence on concussion recovery will aid in future development of genetic counselling. The clinical relevance of genotyping athletes could improve management of athletes who experience concussion injuries.
Metrics
Details
- Title
- Association between GRIN2A promoter polymorphism and recovery from concussion
- Creators
- Jane McDevitt - Temple UniversityRyan Timothy Tierney - Temple UniversityJacqueline Phillips - Temple UniversityJohn P. Gaughan - Biostatistical ConsultingJoseph S. Torg - Temple UniversityEvgeny Krynetskiy - Temple University
- Publication Details
- Brain injury, v 29(13-14), pp 1674-1681
- Publisher
- Informa Healthcare
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Sciences
- Web of Science ID
- WOS:000366659800020
- Scopus ID
- 2-s2.0-84951907727
- Other Identifier
- 991021867192904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Rehabilitation