Journal article
Association between Liver Fibrosis and Serum PSA among U.S. Men: National Health and Nutrition Examination Survey (NHANES), 2001-2010
Cancer epidemiology, biomarkers & prevention, v 28(8), pp 1331-1338
01 Aug 2019
PMID: 31160348
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To evaluate the association of liver fibrosis scores with PSA level among U.S. adult men overall and by race/ethnicity.
Data from the National Health and Nutrition Examination Survey (NHANES), 2001-2010, were used. Males ages ≥40 years without a prostate cancer diagnosis and who had serum PSA, liver enzymes, albumin, and platelet counts measured as part of NHANES protocol were included. Liver fibrosis was measured using three scores: aspartate aminotransferase to platelet ratio index (APRI), fibrosis 4 index (FIB-4), and NAFLD fibrosis score (NFS). We assessed overall and race/ethnicity-stratified geometric mean PSA by fibrosis score using predictive margins by linear regression, and the association of abnormal fibrosis scores (APRI > 1, FIB-4 > 2.67, NFS > 0.676) and elevated PSA (>4 ng/mL) by logistic regression.
A total of 6,705 men were included. Abnormal liver fibrosis scores were present in 2.1% (APRI), 3.6% (FIB-4), and 5.6% (NFS). Men with higher fibrosis scores had lower geometric mean PSA (all
< 0.02). Men with abnormal APRI had a lower odds of PSA > 4 ng/mL [adjusted OR (aOR) = 0.33; 95% confidence interval (CI), 0.11-0.96]. Compared with men with 0 abnormal scores, those with 2 or 3 abnormal fibrosis scores had a lower odds of PSA > 4 ng/mL (aOR = 0.55; 95% CI, 0.33-0.91). The patterns were similar by race/ethnicity.
Men of all race/ethnicities with higher liver fibrosis scores had lower serum PSA, and men with advanced fibrosis scores had a lower odds of an elevated PSA.
These findings support further research to inform the likelihood of delay in prostate cancer detection in men with abnormal liver function.
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Details
- Title
- Association between Liver Fibrosis and Serum PSA among U.S. Men: National Health and Nutrition Examination Survey (NHANES), 2001-2010
- Creators
- Anqi Wang - University of Southern CaliforniaMariana Lazo - Johns Hopkins MedicineH Ballentine Carter - Johns Hopkins MedicineJohn D Groopman - Sidney Kimmel Comprehensive Cancer CenterWilliam G Nelson - Johns Hopkins MedicineElizabeth A Platz - Johns Hopkins Medicine
- Publication Details
- Cancer epidemiology, biomarkers & prevention, v 28(8), pp 1331-1338
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- P30 CA006973 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000481683900008
- Scopus ID
- 2-s2.0-85070774897
- Other Identifier
- 991020550491004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health