Journal article
Association between Oxidative Stress and Masked Hypertension in a Multi-Ethnic Population of Obese Children and Adolescents
The Journal of pediatrics, v 158(4), pp 628-633.e1
2011
PMID: 21075381
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To evaluate whether oxidative stress is correlated with adiposity, obesity-related metabolic abnormalities, and ambulatory blood pressure (ABP) in a multi-ethnic pediatric population.
We conducted a prospective study enrolling 42 obese children (age, 12.8 ± 2.4 years) and 34 non-obese children (age, 11.8 ± 3.4 years). We measured urine 8-isoprostane and hydrogen peroxide (markers of oxidative stress) in both obese and non-obese groups. In the obese group, we measured the 24-hour ABP and obtained an oral glucose tolerance test, lipid panel, interleukin-6, and tumor necrosis factor-α.
8-isoprostane and hydrogen peroxide were correlated with body mass index standard deviation score and waist circumference. The mean 8-isoprostane and hydrogen peroxide levels of the obese group were higher than those of the non-obese group. In the subset of obese subjects who underwent ABP monitoring, 8-isoprostane was correlated with mean 24-hour systolic blood pressure: within the obese group, 8-isoprostane was higher in obese children with elevated mean 24-hour systolic blood pressure.
Our findings provide evidence of a significant correlation between oxidative stress, adiposity, and blood pressure in children. Longitudinal studies in a larger population sample are needed to validate the association between elevated urine 8-isoprostane level and cardiovascular risk factors in an obese pediatric population.
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Details
- Title
- Association between Oxidative Stress and Masked Hypertension in a Multi-Ethnic Population of Obese Children and Adolescents
- Creators
- Vlady Ostrow - St. Christopher's Hospital for ChildrenShufang Wu - St. Christopher's Hospital for ChildrenAlexandra Aguilar - St. Christopher's Hospital for ChildrenRobert Bonner - Drexel UniversityElizabeth Suarez - St. Christopher's Hospital for ChildrenFrancesco De Luca - St. Christopher's Hospital for Children
- Publication Details
- The Journal of pediatrics, v 158(4), pp 628-633.e1
- Publisher
- Mosby, Inc
- Grant note
- Drexel University College of Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine
- Web of Science ID
- WOS:000288242200024
- Scopus ID
- 2-s2.0-79952573077
- Other Identifier
- 991019168245004721
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- Web of Science research areas
- Pediatrics