Journal article
Association between depression and coronary artery calcification in women with systemic lupus erythematosus
Rheumatology (Oxford, England), v 48(5), pp 576-581
01 May 2009
PMID: 19286698
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Abstract
Objectives. To determine the associations between depression, cardiovascular risk factors and coronary artery calcification (CAC) in women with SLE and controls.
Methods. CAC was measured using electron-beam CT (EBCT). Traditional, inflammatory and lupus-related risk factors as well as depressive symptoms (Center for Epidemiologic Studies Depression ScaleCES-D) were measured at a single study visit in 161 women with SLE and 161 age- and race frequency-matched female healthy controls.
Results. Women with SLE reported more depressive symptoms than controls, with 27 of SLE and 15 of controls having CES-D scores suggestive of clinical depression. SLE women were more likely to have CAC, as well as more severe CAC compared with controls. Among the SLE women, depression was associated with greater than 2-fold odds of having any CAC [odds ratio (OR) 2.48; 95 CI 1.05, 5.87; P 0.04], independent of traditional risk factors (age, hypertension and triglycerides) and inflammatory markers. However, when BMI was included among the covariates, the association between depression and CAC was attenuated, indicating the potential mediating role of BMI. Depression was not a risk factor for CAC in controls.
Conclusions. In women with SLE, depression was associated with CAC. This association was mediated by BMI. Depression and adiposity may add to the inflammatory burden of SLE, thus contributing to cardiovascular disease risk.
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Details
- Title
- Association between depression and coronary artery calcification in women with systemic lupus erythematosus
- Creators
- Carol M. Greco - University of PittsburghAmy H. Kao - University of PittsburghAbdus Sattar - University of PittsburghNatalya Danchenko - LundbeckKathleen M. Maksimowicz-McKinnon - University of PittsburghDaniel Edmundowicz - University of PittsburghKim Sutton-Tyrrell - University of PittsburghRussell P. Tracy - University of VermontLewis H. Kuller - University of PittsburghSusan Manzi - University of Pittsburgh
- Publication Details
- Rheumatology (Oxford, England), v 48(5), pp 576-581
- Publisher
- Oxford Univ Press
- Number of pages
- 6
- Grant note
- American College of Rheumatology Research and Education Foundation K24AR002213 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) M01RR000056 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) K23 AR051314; R01 AR46588-01; K24 AR02213-01; K23 AR051044 / National Institutes of Health/National Institute of Arthritis, Musculoskeletal and Skin Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) M01 RR000056 / National Center for Research Resources/General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) UL1TR000005 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000265270300021
- Scopus ID
- 2-s2.0-65249117894
- Other Identifier
- 991021934011904721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology