Journal article
Association between depression and vascular disease in systemic lupus erythematosus
Journal of rheumatology, v 39(2), pp 262-268
01 Feb 2012
PMID: 22174200
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVESystemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with increased prevalence of cardiovascular disease (CVD) and depression. Although depression may contribute to CVD risk in population-based studies, its influence on cardiovascular morbidity in SLE has not been evaluated. We evaluated the association between depression and vascular disease in SLE. METHODSA cross-sectional study was conducted from 2002-2005 in 161 women with SLE and without CVD. The primary outcome measure was a composite vascular disease marker consisting of the presence of coronary artery calcium and/or carotid artery plaque. RESULTSIn total, 101 women met criteria for vascular disease. In unadjusted analyses, several traditional cardiovascular risk factors, inflammatory markers, adiposity, SLE disease-related factors, and depression were associated with vascular disease. In the final multivariable model, the psychological variable depression was associated with nearly 4-fold higher odds for vascular disease (OR 3.85, 95% CI 1.37, 10.87) when adjusted for other risk factors of age, lower education level, hypertensive status, waist-hip ratio, and C-reactive protein. CONCLUSIONIn SLE, depression is independently associated with vascular disease, along with physical factors.
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Details
- Title
- Association between depression and vascular disease in systemic lupus erythematosus
- Creators
- Carol M GrecoTracy LiAbdus SattarAmy H KaoNatalya DanchenkoDaniel EdmundowiczKim Sutton-TyrrellRussell P TracyLewis H KullerSusan Manzi
- Publication Details
- Journal of rheumatology, v 39(2), pp 262-268
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000301008200011
- Scopus ID
- 2-s2.0-84863041537
- Other Identifier
- 991021934009504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology