Journal article
Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children
Environment international, v 134, pp 105302-105302
Jan 2020
PMID: 31726363
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Several animal studies have suggested that fluoride exposure may increase the levels of cardiometabolic risk factors, but little is known about whether fluoride exposure is associated with such risk in humans.
We examined the cross-sectional association between peripubertal exposure to fluoride and markers of cardiometabolic risk in 280 girls and 256 boys at age 10-18 years living in Mexico City.
We measured plasma fluoride concentration using a microdiffusion method. We collected data on anthropometry including BMI, waist circumference (WC) and trunk fat percentage. We measured serum markers of cardiometabolic risk, including fasting glucose, insulin and lipids. All the indicators of outcome were converted to age- and sex-specific z-scores. We also calculated a summary cardiometabolic risk score for each participant. Multivariable linear regression models were used to examine these associations.
The geometric mean (95% confidence interval (CI)) of plasma fluoride was 0.21 μmol/L (0.20, 0.23 μmol/L) in the total sample. In girls, plasma fluoride concentrations were associated with higher z-scores for all the individual markers (except for lipids) and for the combined cardiometabolic risk score (risk score: β = 1.28, 95% CI: 0.57-2.00, p-sex interaction = 0.02)), adjusting for covariates. No associations were found in boys.
We found that higher peripubertal fluoride exposure at the levels observed in this study population was significantly associated with increased levels of cardiometabolic risk factors in Mexican girls but not boys. Future studies with a longitudinal design are needed to confirm our findings and further elucidate the role of fluoride in cardiometabolic risk.
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Details
- Title
- Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children
- Creators
- Yun Liu - University of MichiganMartha Téllez-Rojo - Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.Brisa N Sánchez - University of MichiganAdrienne S Ettinger - University of MichiganCitlalli Osorio-Yáñez - Universidad Nacional Autónoma de MéxicoMaritsa Solano - Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.Howard Hu - University of WashingtonKaren E Peterson - University of Michigan
- Publication Details
- Environment international, v 134, pp 105302-105302
- Publisher
- Elsevier
- Grant note
- R01 ES007821 / NIEHS NIH HHS P30 DK020572 / NIDDK NIH HHS R01 ES021446 / NIEHS NIH HHS P01 ES022844 / NIEHS NIH HHS P20 ES018171 / NIEHS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000501344500010
- Scopus ID
- 2-s2.0-85074572705
- Other Identifier
- 991020100201204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences