Journal article
Association between perioperative prealbumin level and outcomes in coronary bypass surgery patients
Coronary artery disease, v 37(2), pp 127-132
Mar 2026
PMID: 40916781
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Albumin and BMI have been used as nutritional markers of morbidity and mortality. Recently, prealbumin has grown in interest in other surgical disciplines, but less so in cardiac surgery. Thus, this study examined the association between prealbumin and bleeding, mortality, and readmission in coronary artery bypass graft (CABG) patients.
A retrospective review was performed on all patients undergoing CABG at a single institution from July 2017 to December 2021. Study patients underwent CABG as part of an isolated or combined procedure and had a perioperative prealbumin measurement. The primary study endpoints were intra- and post-operative bleeding, and mortality and hospital readmission within 30 days.
A total of 1211 patients underwent CABG surgery and had a documented perioperative prealbumin. Prealbumin levels were stratified as ≤10, 10-15, 15-20, or >20 mg/dl. There were no differences across prealbumin groups in preoperative antiplatelet use, anticoagulant use, or concomitant procedures. Patients with low prealbumin were more likely to be older, female, and to have an urgent myocardial infarction presentation with lower preoperative BMI and albumin. In adjusted models including albumin and BMI, CABG patients with prealbumin ≤10 mg/dl were more likely to receive any intraoperative [odds ratio (OR) = 3.11, 95% confidence interval (CI): 1.43, 6.75] or postoperative transfusion (OR = 2.54, 95% CI: 1.27, 5.08) compared to patients with prealbumin >20 mg/dl. Patients with a lower prealbumin had higher 30-day mortality ( P < 0.001) and readmission rates ( P = 0.06).
Perioperative prealbumin levels were associated with blood transfusions, mortality, and readmissions in CABG patients.
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Details
- Title
- Association between perioperative prealbumin level and outcomes in coronary bypass surgery patients
- Creators
- Andrew P Rabenstein - Allegheny General HospitalRishabh Matta - Allegheny Health NetworkBrent A Williams - Allegheny Health NetworkJeanette Brocious - Allegheny Health NetworkRodrigo Campana - Allegheny Health NetworkAryan Meknat - Drexel University, SurgerySean Forrest - Allegheny Health NetworkStephen Bailey - Drexel University, Cardiothoracic SurgeryMichael S Halbreiner - Allegheny General Hospital
- Publication Details
- Coronary artery disease, v 37(2), pp 127-132
- Publisher
- Coronary artery disease
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery; Surgery
- Web of Science ID
- WOS:001676134500015
- Scopus ID
- 2-s2.0-105015449359
- Other Identifier
- 991022092350304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems