Journal article
Association between prenatal lead exposure and blood pressure in children
Environmental health perspectives, v 120(3), pp 445-450
Mar 2012
PMID: 21947582
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Lead exposure in adults is associated with hypertension. Altered prenatal nutrition is associated with subsequent risks of adult hypertension, but little is known about whether prenatal exposure to toxicants, such as lead, may also confer such risks.
We investigated the relationship of prenatal lead exposure and blood pressure (BP) in 7- to 15-year-old boys and girls.
We evaluated 457 mother-child pairs, originally recruited for an environmental birth cohort study between 1994 and 2003 in Mexico City, at a follow-up visit in 2008-2010. Prenatal lead exposure was assessed by measurement of maternal tibia and patella lead using in vivo K-shell X-ray fluorescence and cord blood lead using atomic absorption spectrometry. BP was measured by mercury sphygmomanometer with appropriate-size cuffs.
Adjusting for relevant covariates, maternal tibia lead was significantly associated with increases in systolic BP (SBP) and diastolic BP (DBP) in girls but not in boys (p-interaction with sex = 0.025 and 0.007 for SBP and DBP, respectively). Among girls, an interquartile range increase in tibia lead (13 μg/g) was associated with 2.11-mmHg [95% confidence interval (CI): 0.69, 3.52] and 1.60-mmHg (95% CI: 0.28, 2.91) increases in SBP and DBP, respectively. Neither patella nor cord lead was associated with child BP.
Maternal tibia lead, which reflects cumulative environmental lead exposure and a source of exposure to the fetus, is a predisposing factor to higher BP in girls but not boys. Sex-specific adaptive responses to lead toxicity during early-life development may explain these differences.
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Details
- Title
- Association between prenatal lead exposure and blood pressure in children
- Creators
- Aimin Zhang - Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109-2029, USA. aiminz@umich.eduHoward HuBrisa N SánchezAdrienne S EttingerSung Kyun ParkDavid CantonwineLourdes SchnaasRobert O WrightHector Lamadrid-FigueroaMartha Maria Tellez-Rojo
- Publication Details
- Environmental health perspectives, v 120(3), pp 445-450
- Publisher
- United States
- Grant note
- R01 ES007821 / NIEHS NIH HHS K23 ES000381 / NIEHS NIH HHS R01 ES013744 / NIEHS NIH HHS R01 ES020268 / NIEHS NIH HHS K01 ES016587 / NIEHS NIH HHS T32 ES007062 / NIEHS NIH HHS P30 DK020572 / NIDDK NIH HHS T32 ES07062 / NIEHS NIH HHS K01 ES014907 / NIEHS NIH HHS T32 DK071212 / NIDDK NIH HHS R01 ES014930 / NIEHS NIH HHS P42 ES016454 / NIEHS NIH HHS DK071212 / NIDDK NIH HHS P30 ES017885 / NIEHS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000301394700035
- Scopus ID
- 2-s2.0-84863289145
- Other Identifier
- 991014878263104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology