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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Association between the soluble receptor for advanced glycation end products (sRAGE) and NAFLD in participants in the Atherosclerosis Risk in Communities Study
Digestive and liver disease, v 53(7), pp 873-878
01 Jul 2021
PMID: 33640303
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inflammation is key in the pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD) – a common progressive liver disease. The soluble receptor for advanced glycation end products (sRAGE) attenuates inflammatory signaling; low levels of sRAGE are correlated with increased inflammation.
We sought to describe associations between sRAGE and NAFLD.
We conducted a cross-sectional analysis of 1088 Atherosclerosis Risk in Communities (ARIC) Study participants and used logistic regression to investigate the associations between sRAGE and NAFLD defined by elevated liver enzymes and fibrosis score.
In this community-based sample (n = 1,088, mean age 56 years, 61% female, 78% Caucasian), persons in the lowest vs. highest quartile of sRAGE had significantly higher odds of elevated ALT (OR 2.82, 95% CI 1.18-6.76) but not elevated AST (OR 1.16, 95% CI 0.45-2.99); persons in the lowest vs. highest quartile had significantly lower odds of elevated FIB-4 index (OR 0.56, 95% CI 0.37-0.84).
We found an inverse cross-sectional association between sRAGE and liver inflammation; this is consistent with prior studies linking low sRAGE to inflammatory states. However, we observed a direct association between sRAGE and fibrosis. Our findings suggest that sRAGE is dynamic in NAFLD and patterns may vary with different stages of disease.
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Details
- Title
- Association between the soluble receptor for advanced glycation end products (sRAGE) and NAFLD in participants in the Atherosclerosis Risk in Communities Study
- Creators
- Marci Laudenslager - Johns Hopkins MedicineMariana Lazo - Drexel UniversityDan Wang - Bloomberg (United States)Elizabeth Selvin - Johns Hopkins MedicinePo-Hung Chen - Department of Medicine, Division of Gastroenterology and Hepatology, The Johns Hopkins School of Medicine, Baltimore, MD, United StatesJames S. Pankow - University of MinnesotaJeanne M. Clark - Johns Hopkins Medicine
- Publication Details
- Digestive and liver disease, v 53(7), pp 873-878
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000670070300015
- Scopus ID
- 2-s2.0-85101502636
- Other Identifier
- 991020550339504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology