Journal article
Association of Blood Pressure and Cognition after Stroke
Journal of stroke and cerebrovascular diseases, v 29(7), 104754
Jul 2020
PMID: 32370925
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and Aim: It is unclear whether blood pressure (BP) is associated with cognition after stroke. We examined associations between systolic and diastolic BP (SBP, DBP), pulse pressure (PP), mean arterial pressure (MAP), and cognition, each measured 90 days after stroke. Methods: Cross-sectional analysis of prospectively obtained data of 432 dementia-free subjects greater than or equal to 45 (median age, 66; 45% female) with stroke (92% ischemic; median NIH stroke score, 3 [IQR, 2-6]) from the population-based Brain Attack Surveillance in Corpus Christi (BASIC) project in 2011-2013. Primary outcome: Modified Mini-Mental Status Examination (3MSE; range, 0-100). Secondary outcomes: Animal Fluency Test (AFT; range, 0-10) and Trail Making Tests A and B (number of correct items [range, 0-25]/completion time [Trails A: 0-180 seconds; Trails B: 0-300 second]). Linear or tobit regression adjusted associations for age, education, and race/ethnicity as well as variables significantly associated with BP and cognition. Results: Higher SBP, lower DBP, higher PP, and lower MAP each were associated with worse cognitive performance for all 4 tests (all P < .001). After adjusting for patient factors, no BP measures were associated with any of the 4 tests (all P > .05). Lower cognitive performance was associated with older age, less education, Mexican American ethnicity, diabetes, higher stroke severity, more depressive symptoms, and lower BMI. Among survivors with hypertension, anti-hypertensive medication use 90 days after stroke was significantly associated with higher AFT scores (P = .02) but not other tests (P > .15). Conclusions: Stroke survivors’ BP levels were not associated with cognitive performance at 90 days independent of sociodemographic and clinical factors.
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Details
- Title
- Association of Blood Pressure and Cognition after Stroke
- Creators
- Deborah A. Levine - University of MichiganAndrzej T. Galecki - University of MichiganDolorence Okullo - University of MichiganEmily M. Briceño - University of MichiganMohammed U. Kabeto - University of MichiganLewis B. Morgenstern - University of MichiganKenneth M. Langa - VA Ann Arbor Healthcare SystemBruno Giordani - University of MichiganRobert Brook - University of MichiganBrisa N. Sanchez - Drexel UniversityLynda D. Lisabeth - University of Michigan
- Publication Details
- Journal of stroke and cerebrovascular diseases, v 29(7), 104754
- Publisher
- Elsevier
- Grant note
- P30 AG024824 / NIH/NIA K23 AG040278 / NIH/NIA R01 NS102715 / NIH/NINDS R01 NS38916 / NIH/NINDS R01 AG 051827 / NIH/NIA P30 AG053760; P30 AG024824 / NIH/NIA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000539258500039
- Scopus ID
- 2-s2.0-85084141794
- Other Identifier
- 991020099858704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Peripheral Vascular Disease