Journal article
Association of Carotid Artery Endothelial Signal Intensity Gradient with Unilateral Large Artery Ischemic Stroke
Cerebrovascular diseases (Basel, Switzerland), v 50(3)
01 May 2021
PMID: 33756458
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Common carotid artery (CCA) and internal carotid artery (ICA) are aligned linearly, but their hemodynamic role in ischemic stroke has not been studied in depth. Objectives: We aimed to investigate whether CCA and ICA endothelial shear stress (ESS) could be associated with the ischemic stroke of large artery atherosclerosis (LAA). Methods: We enrolled consecutive patients with unilateral ischemic stroke of LAA and healthy controls aged >60 years in the stroke center of Jeonbuk National University Hospital. All patients and controls were examined with carotid artery time-of-flight magnetic resonance angiography, and their endothelial signal intensity gradients (SIGs) were determined, as a measure of ESS. The effect of right or left unilateral stroke on the association between carotid artery endothelial SIG and ischemic stroke of LAA was assessed. Results: In total, the results from 132 patients with ischemic stroke of LAA and 121 controls were analyzed. ICA endothelial SIG showed significant and independent associations with the same-sided unilateral ischemic stroke of LAA, even after adjusting for the potential confounders including carotid stenosis, whereas CCA endothelial SIG showed a significant association with the presence of the ischemic stroke of LAA. Conclusion: Although CCA and ICA are located with continuity, the hemodynamics and their roles in large artery ischemic stroke should be considered separately. Further studies are needed to delineate the pathophysiologic roles of ESS in CCA and ICA for large artery ischemic stroke.
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Details
- Title
- Association of Carotid Artery Endothelial Signal Intensity Gradient with Unilateral Large Artery Ischemic Stroke
- Creators
- Chan-Hyuk Lee - Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Dept Neurol,Biomed Res Inst, Jeonju, South KoreaSang Hyuk Lee - Korea Inst Machinery & Mat, Equipment Qualificat Ctr Nucl Power Plants, Daejeon, South KoreaYoung I. Cho - Drexel UniversitySeul-Ki Jeong - Visual Intelligence Laboratory, Seul-Ki Jeong Neurology Clinic, Seoul, Republic of Korea,
- Publication Details
- Cerebrovascular diseases (Basel, Switzerland), v 50(3)
- Publisher
- Karger
- Number of pages
- 9
- Grant note
- CUH2014-05019002 / Biomedical Research Institute, Jeonbuk National University Hospital
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000632538800001
- Scopus ID
- 2-s2.0-85103431366
- Other Identifier
- 991019167687404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Peripheral Vascular Disease