Journal article
Association of Graft Survival with Host Response to Hepatitis B Infection in Patients with Kidney Transplants
The New England journal of medicine, v 296(5), pp 241-244
03 Feb 1977
PMID: 318732
Abstract
We studied the relation of host response to hepatitis B infection before transplantation with survival of kidney grafts in 79 patients receiving 87 transplants. Antibody to hepatitis B surface antigen (anti-HB
s
) signaled early graft rejection (median survival ≈ two months), whereas hepatitis B surface antigen (HB
s
Ag) signaled delayed rejection (>22 months). Patients with neither HB
s
Ag nor anti-HB
s
had graft survival times (median ≈ 16 months) similar to the HB
s
Ag carriers but significantly longer than the anti-HB
s
-positive patients (P<0.01). Similar results were observed when patients who received HLA-identical kidneys or had anti-HLA antibodies before transplantation were excluded. The highest probability of graft rejection was in patients with anti-HB
s
who received kidneys from male donors. The probability that such grafts would survive for four months was <20 per cent.
HLA-nonidentical kidneys transplanted into patients with anti-HB
s
have a poor prognosis, whereas such grafts in HB
s
Ag carriers have as good a prognosis as grafts in uninfected recipients. (N Engl J Med 296:241–244, 1977)
Infection with hepatitis B virus is common in patients undergoing chronic hemodialysis and in patients who have received kidney transplants,
1
,
2
but whether the infection affects the prognosis of these patients is uncertain.
3
,
4
To gain information on this point we have tested the hypothesis that there is a relation between the host response to the virus and the host response to a kidney graft.
Materials and Methods
Patients
Since November, 1970, we have obtained monthly blood specimens from patients and staff of a commercial hemodialysis clinic in Philadelphia. Fifty-two of these patients received one or more kidney transplants (60 total) before . . .
Metrics
Details
- Title
- Association of Graft Survival with Host Response to Hepatitis B Infection in Patients with Kidney Transplants
- Creators
- W. Thomas LondonJean S DrewBaruch S BlumbergRobert A GrossmanPatricia J Lyons
- Publication Details
- The New England journal of medicine, v 296(5), pp 241-244
- Publisher
- Massachusetts Medical Society
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nephrology (and Hypertension)
- Web of Science ID
- WOS:A1977CT97900002
- Scopus ID
- 2-s2.0-0017360667
- Other Identifier
- 991019173869204721