Journal article
Association of Hospitalization for Infection in Childhood With Diagnosis of Autism Spectrum Disorders A Danish Cohort Study
Archives of pediatrics & adolescent medicine, v 164(5), pp 470-477
01 May 2010
PMID: 20439799
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To investigate the association between hospitalization for infection in the perinatal/neonatal period or childhood and the diagnosis of autism spectrum disorders (ASDs).
Design: A population-based cohort study.
Setting: Denmark.
Participants: All children born in Denmark from January 1, 1980, through December 31, 2002, comprising a total of 1 418 152 children.
Exposure: Infection requiring hospitalization.
Main Outcome Measure: The adjusted hazard ratio (HR) for ASDs among children hospitalized for infection compared with other children.
Results: A total of 7379 children were diagnosed as having ASDs. Children admitted to the hospital for any infectious disease displayed an increased rate of ASD diagnoses (HR, 1.38 [95% confidence interval, 1.31-1.45]). This association was found to be similar for infectious diseases of bacterial and viral origin. Furthermore, children admitted to the hospital for noninfectious disease also displayed an increased rate of ASD diagnoses (HR, 1.76 [95% confidence interval, 1.68-1.86]), and admissions for infection increased the rate of mental retardation (2.18 [2.06-2.31]).
Conclusions: The association between hospitalization for infection and ASDs observed in this study does not suggest causality because a general association is observed across different infection groups. Also, the association is not specific for infection or for ASDs. We discuss a number of noncausal explanatory models.
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Details
- Title
- Association of Hospitalization for Infection in Childhood With Diagnosis of Autism Spectrum Disorders A Danish Cohort Study
- Creators
- Hjordis Osk Atladottir - Aarhus UniversityPoul ThorsenDiana E. Schendel - Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USALars Ostergaard - Arhus Univ Hosp, Dept Infect Dis, Res Unit Q, Skejby, DenmarkSaane Lemcke - Aarhus UniversityErik T. Parner - Aarhus University
- Publication Details
- Archives of pediatrics & adolescent medicine, v 164(5), pp 470-477
- Publisher
- Amer Medical Assoc
- Number of pages
- 8
- Grant note
- Lundbeck Foundation; Lundbeckfonden Familien Hede Nielsens Foundation Arhus University Research Foundation Augustinus Foundation Aase and Ejnar Danielsens Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000277261100012
- Scopus ID
- 2-s2.0-77951966593
- Other Identifier
- 991021229892004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics