Journal article
Association of Methylenetetrahydrofolate Reductase (MTHFR) A1298C Polymorphism with Lower High-Density Lipoprotein Cholesterol Level
Annals of clinical and laboratory science, v 49(2)
Mar 2019
PMID: 31028069
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Evidences about the relationship between methylenetetrahydrofolate reductase
gene polymorphism and metabolic syndrome are controversial. The present study aimed to investigate if
gene polymorphisms
and
are related to metabolic syndrome (MS).
318 patients were enrolled and single nucleotide polymorphisms for
and
were genotyped. BMI, fasting blood glucose level (FBG), total cholesterol (TC), low-density lipoprotein (LDL), High-density lipoprotein (HDL) and triglycerides (TG) were measured.
In our study population, there were no significant differences for BMI, FBG, TC, LDL, TG or any component disease of MS between
,
wild type and variants.
wild type had significant higher HDL level than
variants (50.9±1.6 VS. 47.1±1.0,
=0.036). Binary logistic regression analysis also showed that
variants were significantly associated with lower HDL level (OR=0.963, 95%CI 0.93-0.99,
=0.027). General linear model showed that there was no statistically significant interaction between
and
gene polymorphism on HDL level. So the reduction in HDL in
variants was not due to its linkage disequilibrium with the
polymorphism or an interaction between
and
genotypes.
Our study suggests that
gene polymorphism is not related to any components of metabolic syndrome.
variants were significantly associated with lower HDL level compared to
wild type.
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Details
- Title
- Association of Methylenetetrahydrofolate Reductase (MTHFR) A1298C Polymorphism with Lower High-Density Lipoprotein Cholesterol Level
- Creators
- Milan Mahesh - Moravian Academy, Bethlehem, PA, USAGang Cheng - Easton Hospital, Easton, PA, USAKoroush Khalighi - Drexel University
- Publication Details
- Annals of clinical and laboratory science, v 49(2)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:000503158200012
- Scopus ID
- 2-s2.0-85065335645
- Other Identifier
- 991019168286804721
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