Journal article
Association of Normative and Non-Normative Brain Networks With Cognitive Function in Patients With Temporal Lobe Epilepsy
Neurology, v 103(7), 209800
08 Oct 2024
PMID: 39250744
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and Objectives Despite their temporal lobe pathology, a significant subgroup of patients with temporal lobe epilepsy (TLE) is able to maintain normative cognitive functioning. In this study, we identify patients with TLE with intact vs impaired neurocognitive profiles and interrogate for the presence of both normative and highly individual intrinsic connectivity networks (ICNs)-all toward understanding the transition from impaired to intact neurocognitive status. Methods This retrospective cross-sectional study included patients with TLE and matched healthy controls (HCs) from the Thomas Jefferson Comprehensive Epilepsy Center. Functional MRI data were decomposed using independent component analysis to obtain individualized ICNs. In this article, we calculated the degree of match between individualized ICNs and canonical ICNs (e.g., 17 resting-state networks by Yeo et al.) and divided each participant's ICNs into normative or non-normative status based on the degree of match. Results 100 patients with TLE (mean age 42.0 [SD: 13.7] years, 47 women) and 92 HCs were included in this study. We found that the individualized networks matched to the canonical networks less well in the cognitively impaired (n = 24) compared with the cognitively intact (n = 63) patients with TLE by 2-way mixed-measures analysis of variance (impaired vs intact mean difference [MD] -0.165 [-0.317, -0.013], p = 0.028). The cognitively impaired patients showed significant abnormalities in the profiles of both normative (impaired vs intact MD -0.537 [-0.998, -0.076], p = 0.017, intact vs HC MD -0.221 [-0.536, 0.924], p = 0.220, and impaired vs HC MD -0.759 [-1.200, -0.319], p < 0.001) and non-normative networks (impaired vs intact MD 0.484 [0.030, 0.937], p = 0.033, intact vs HC MD 0.369 [0.059, 0.678], p = 0.014, and impaired vs HC MD 0.853 [0.419, 1.286], p < 0.001) while the intact patients showed abnormalities only in non-normative networks. At the same time, we found that normative networks held a strong, positive association with the neuropsychological measures, with this association negative in non-normative networks. Discussion Our data demonstrated that significant cognitive deficits are associated with the status of both canonical and highly individual ICNs, making clear that the transition from intact to impaired cognitive status is not simply the result of disruption to normative brain networks.
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Details
- Title
- Association of Normative and Non-Normative Brain Networks With Cognitive Function in Patients With Temporal Lobe Epilepsy
- Creators
- Qirui Zhang - Thomas Jefferson UniversityStacy Hudgins - Thomas Jefferson UniversityAaron F. Struck - Thomas Jefferson UniversityAnkeeta Ankeeta - Thomas Jefferson UniversitySam S. Javidi - Thomas Jefferson UniversityMichael R. Sperling - Thomas Jefferson UniversityBruce P. Hermann - Thomas Jefferson UniversityJoseph I. Tracy - Thomas Jefferson University
- Publication Details
- Neurology, v 103(7), 209800
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 13
- Grant note
- R01NS112816-01 / JIT, NIH/National Institute of Neurological Disorders and Stroke
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering and Science
- Web of Science ID
- WOS:001397723500001
- Scopus ID
- 2-s2.0-85203763177
- Other Identifier
- 991022202106804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology