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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Association of Sugar Intake with Inflammation- and Angiogenesis-Related Biomarkers in Newly Diagnosed Colorectal Cancer Patients
Nutrition and cancer, v 74(5), pp 1636-1643
28 May 2022
PMID: 34369225
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Evidence suggests a positive association between sugar intake and colorectal cancer (CRC) outcomes. We sought to investigate inflammation and angiogenesis as underlying mechanisms behind increased sugar intake and worse CRC outcomes. Pre-surgery serum samples were obtained from 191 patients diagnosed with primary invasive stage I-IV CRC. Biomarkers of inflammation (CRP, SAA, IL-6, IL-8, MCP-1, TNF alpha) and angiogenesis (VEGFA, VEGFD, sICAM-1 and sVCAM-1) were analyzed (Meso-Scale-Discovery). Fructose, glucose, sucrose, and total sugar intake (calories/day, % total calories) were assessed by FFQ. Pearson's correlation and multiple linear regression analyses were performed. Patients were on average 64 years old, 64% were male, the majority was diagnosed with stage II-III (58%) cancers, and 67% were either overweight or obese. Among normal-weight individuals (BMI <25 kg/m(2)), we observed a significant inverse association between VEGFD and any type of sugar intake in cal/day (sucrose: p = 0.01, glucose and fructose: p < 0.001) and MCP-1 and fructose intake (p = 0.05). The magnitude of reduction in VEGF ranged between -1.24 for sucrose to 4.49 for glucose intake, and -2.64 for fructose intake for MCP-1 levels. Sugar intake was associated with some inflammation or angiogenesis biomarkers, among CRC patients; differences were observed by adiposity that warrant further investigation. Supplemental data for this article is available online at at 10.1080/01635581.2021.1957133.
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Details
- Title
- Association of Sugar Intake with Inflammation- and Angiogenesis-Related Biomarkers in Newly Diagnosed Colorectal Cancer Patients
- Creators
- Kelly L. Stewart - University of UtahBiljana Gigic - University Hospital HeidelbergCaroline Himbert - University of UtahChristy A. Warby - University of UtahJennifer Ose - University of UtahTengda Lin - University of UtahPetra Schrotz-King - National Center for Tumor DiseasesJurgen Boehm - University of UtahKristine C. Jordan - University of UtahJulie Metos - University of UtahMartin Schneider - University Hospital HeidelbergJane C. Figueiredo - Cedars-Sinai Medical CenterChristopher Li - Fred Hutch Cancer CenterDavid Shibata - University of Tennessee Health Science CenterErin Siegel - Moffitt Cancer CenterAdetunji T. Toriola - Washington University in St. LouisSheetal Hardikar - University of UtahCornelia M. Ulrich - University of Utah
- Publication Details
- Nutrition and cancer, v 74(5), pp 1636-1643
- Publisher
- Taylor & Francis
- Number of pages
- 8
- Grant note
- Matthias Lackas Foundation Claussen-Simon Stiftung, Germany German Consortium of Translational Cancer Research (DKTK) the German Cancer Research Center (Division of Preventive Oncology) Stiftung LebensBlicke Huntsman Cancer Foundation U01 CA206110; K07 CA222060; R01 CA207371; R01 CA189184; R01 CA211705 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000683159900001
- Scopus ID
- 2-s2.0-85112037057
- Other Identifier
- 991019415662904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Nutrition & Dietetics
- Oncology