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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Association of Waist Circumference and Body Mass Index With All-Cause Mortality in CKD: The REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study
American journal of kidney diseases, v 58(2), pp 177-185
2011
PMID: 21601327
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Abstract
Obesity management requires understanding the mortality risks associated with different adiposity measures.
Prospective cohort.
5,805 adults with body mass index (BMI) ≥18.5 kg/m
2 and stages 1-4 chronic kidney disease, defined as a spot urine albumin-creatinine ratio ≥30 mg/g and/or estimated glomerular filtration rate <60 mL/min/1.73 m
2, enrolled in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.
BMI categorized as 18.5-24.9, 25.0-29.9, 30.0-34.9, 35.0-39.9, and ≥40 kg/m
2 and waist circumference categorized as <80, 80-87.9, 88-97.9, 98-107.9, and ≥108 cm in women and <94, 94-101.9, 102-111.9, 112-121.9, and ≥122 cm in men.
All-cause mortality.
BMI and waist circumference were measured using a standardized protocol during the home visit.
686 (11.8%) deaths occurred during a median follow-up of 4 years. Compared with the referent BMI category of 25-29.9 kg/m
2, HRs for mortality were 1.27 (95% CI, 0.96-1.69) for BMI <25 kg/m
2 and 0.84 (95% CI, 0.62-1.13), 0.81 (95% CI, 0.52-1.26), and 0.95 (95% CI, 0.54-1.65) for BMI categories 30-34.9, 35-39.9, and ≥40 kg/m
2 after adjustment for covariates including waist circumference, respectively. In contrast, after adjustment for covariates including BMI, higher mortality rates were noted for all waist circumference categories compared with the referent (<80 cm in women and <94 cm in men), with HRs of 1.04 (95% CI, 0.77-1.41) for waist circumference of 80-87.9 cm in women and 94-101.9 cm in men, 1.29 (95% CI, 0.92-1.81) for waist circumference of 88-97.9 cm in women and 102-111.9 cm in men, 1.72 (95% CI, 1.12-2.62) for waist circumference of 98-107.9 cm in women and 112-121.9 cm in men, and 2.09 (95% CI, 1.26-3.46) for waist circumference ≥108 cm in women and ≥122 cm in men.
BMI and waist circumference measured at baseline only.
Waist circumference should be considered in conjunction with BMI when assessing mortality risk associated with obesity in adults with chronic kidney disease.
Metrics
Details
- Title
- Association of Waist Circumference and Body Mass Index With All-Cause Mortality in CKD: The REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study
- Creators
- Holly Kramer - Loyola University Medical CenterDavid Shoham - Loyola University Medical CenterLeslie A. McClure - University of Alabama at BirminghamRamon Durazo-Arvizu - Loyola University Medical CenterGeorge Howard - University of Alabama at BirminghamSuzanne Judd - University of Alabama at BirminghamPaul Muntner - University of Alabama at BirminghamMonika Safford - University of Alabama at BirminghamDavid G. Warnock - University of Alabama at BirminghamWilliam McClellan - Emory University
- Publication Details
- American journal of kidney diseases, v 58(2), pp 177-185
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000293010000007
- Scopus ID
- 2-s2.0-79960830025
- Other Identifier
- 991019231632204721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Urology & Nephrology