Journal article
Association of aortic valve disease with intestinal angioectasia: Data from the Nationwide Inpatient Sample
European journal of gastroenterology & hepatology, v 30(4), pp 438-441
Apr 2018
PMID: 29369835
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective
Since the description of a correlation between aortic stenosis and angioectasia, controversy has persisted about whether these diseases are truly associated or coincidental findings of older age. Our objective was to determine the association of aortic valve disease and bleeding intestinal angioectasia from a large database.
Patients and methods
We used the 2011 Nationwide Inpatient Sample database to identify hospitalizations in the USA in patients with bleeding intestinal angioectasia. International Classification of Diseases, 9th revision, Clinical Modification codes were used to identify patients with aortic valve disease, mitral valve disease, and known risk factors for angioectasia (including diagnosed von Willebrand disease, left ventricular assist device, and chronic kidney disease). Univariate and multivariate logistic regression were used to determine the odds of association between the valvular diseases and angioectasia.
Results
A total of 32 079 intestinal angioectasia-related hospitalizations were identified of which 7.02% (n=2253) cases had coexistent aortic valve disease. The unadjusted odds of aortic valve disease in association with bleeding intestinal angioectasia versus those without bleeding angioectasia was 4.95 [95% confidence interval: (CI): 4.43–5.54, P<0.001]. The association of intestinal angioectasia with mitral valve disease was not significant (odds ratio=1.56, 95% CI: 0.59–4.14, P=0.38). When adjusted for age and known risk factors, the odds of aortic valve disease in bleeding intestinal angioectasia was still significant (odds ratio=2.37, 95% CI: 2.10–2.66, P<0.001).
Conclusion
Our findings support an important association between aortic valve disease and bleeding intestinal angioectasia, not identified in valvular heart valvular diseases with lower shear stress (mitral valve disease).
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Details
- Title
- Association of aortic valve disease with intestinal angioectasia: Data from the Nationwide Inpatient Sample
- Creators
- Asad Jehangir - Reading HospitalRanjan Pathak - Yale UniversityAnene Ukaigwe - Penn State Milton S. Hershey Medical CenterAnthony A. Donato - Reading Hospital
- Publication Details
- European journal of gastroenterology & hepatology, v 30(4), pp 438-441
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 4
- Grant note
- Healthcare Cost and Utilization Project Agency for Healthcare Research and Quality (http://data.elsevier.com/vocabulary/SciValFunders/100000133) National Intelligence Service (http://data.elsevier.com/vocabulary/SciValFunders/501100003581)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000429054500013
- Scopus ID
- 2-s2.0-85044294647
- Other Identifier
- 991022161837104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology