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Association of blood group and red blood cell transfusion with the incidence of antepartum, peripartum and postpartum venous thromboembolism
Journal article   Open access   Peer reviewed

Association of blood group and red blood cell transfusion with the incidence of antepartum, peripartum and postpartum venous thromboembolism

Chen Wang, Isabelle Le Ray, Brian Lee, Agneta Wikman and Marie Reilly
Scientific reports, v 9(1), pp 13535-13535
19 Sep 2019
DOI: https://doi.org/10.1038/s41598-019-49566-3
PMID: 31537816
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1038/s41598-019-49566-3View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

Adult Blood Group Antigens - metabolism Cohort Studies Erythrocyte Transfusion - adverse effects Erythrocyte Transfusion - methods Female Humans Incidence Odds Ratio Peripartum Period Postpartum Period Pregnancy Complications - etiology Risk Assessment Risk Factors Thrombophilia - etiology Venous Thromboembolism - blood Venous Thromboembolism - epidemiology Venous Thromboembolism - pathology Venous Thrombosis - etiology Pregnancy Sweden
The increased risk of venous thromboembolism (VTE) associated with pregnancy is well-known and prophylaxis guidelines consider a number of risk factors. Although non-O blood group and red blood cell (RBC) transfusion are known to be associated with VTE risk, their contribution to pregnancy-associated VTE has received little attention. This study was conducted in a population-based cohort of 1,000,997 deliveries to women with no prior history of VTE or thrombophilia. The independent contributions of ABO blood type and RBC transfusion to the risks of antepartum, peripartum and postpartum VTE are reported as odds ratios adjusted for risk factors that are considered in current prophylaxis guidelines and other potential confounders. Compared with type O, A and B blood types have higher risk of antepartum and postpartum VTE, with odds ratios between 1.4 and 1.8. Transfusion around delivery has the largest increased risks and a dose-response effect, with adjusted odds ratios from 2.60 (1.71-3.97) for 1-2 units to 3.55 (1.32-9.55) for more than 5 units. ABO blood type and RBC transfusion were found to be independent risk factors for pregnancy-associated VTE. Further research is required to understand the underlying mechanisms and to conduct a risk-benefit assessment of the small volumes of RBCs transfused around delivery.

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11 citations in Web of Science
14 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Hematology
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