Journal article
Association of blood leukocyte DNA methylation at LINE-1 and growth-related candidate genes with pubertal onset and progression
Epigenetics, v 13(12), pp 1222-1233
01 Jan 2018
PMID: 30582410
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Puberty is a developmentally plastic phase. Variations in pubertal tempo have implications for the risk of later adult diseases. Influences on pubertal tempo have been widely discussed, but the underlying biological mechanisms remain unclear. Epigenetic modifications are known to regulate development processes; they could play an important role in affecting pubertal outcomes. We conducted a population-based analysis to investigate the association of peripubertal blood DNA methylation at LINE-1 and growth-related candidate genes with pubertal onset and progression in healthy adolescents. The analytic sample included 114 males and 129 females aged 10 to 18 years. DNA methylation at growth-related candidate loci IGF2, H19, HSD11B2, as well as LINE-1 repetitive elements were quantified. Cox survival and ordinal regression models were used to examine sex-and locus-specific associations of epigenetic markers with pubertal development using physician-assessed Tanner stages and self-reported menarche, adjusted for covariates. Among boys, DNA methylation at H19 was associated with later pubarche. HSD11B2 methylation was associated with earlier onset of pubic hair and genitalia development and slower pubertal progression. IGF2 was associated with later onset of genital development. Among girls, LINE-1 methylation was associated with later onset of breast development. For each percent increase of methylation at H19, there was 5% increased odds in the earlier onset of breast development. DNA methylation of IGF2 was associated with earlier onset of pubic hair. DNA methylation at genes known to influence early-life growth may also influence pubertal outcomes.
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Details
- Title
- Association of blood leukocyte DNA methylation at LINE-1 and growth-related candidate genes with pubertal onset and progression
- Creators
- Yue Wu - University of MichiganKaren E. Peterson - University of MichiganBrisa N. Sanchez - University of MichiganDana C. Dolinoy - Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI 48109 USAAdriana Mercado-Garcia - e Center for Research on Nutrition and Health, National Institute of Public Health , Cuernavaca , Morelos , México.Martha M. Tellez-Rojo - e Center for Research on Nutrition and Health, National Institute of Public Health , Cuernavaca , Morelos , México.Jaclyn M. Goodrich - University of Michigan
- Publication Details
- Epigenetics, v 13(12), pp 1222-1233
- Publisher
- Taylor & Francis
- Number of pages
- 12
- Grant note
- P20 ES018171; P01 ES02284401; R01 ES007821; P30 ES017885 / National Institute for Environmental Health Sciences (NIEHS); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) National Institute of Public Health/Ministry of Health of Mexico R01ES013744 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) RD834800; RD83543601 / U.S. Environmental Protection Agency (US EPA); United States Environmental Protection Agency
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000456104900006
- Scopus ID
- 2-s2.0-85059032144
- Other Identifier
- 991020100202704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Genetics & Heredity