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Association of cetuximab with adverse pulmonary events in cancer patients: a comprehensive review
Journal article   Open access   Peer reviewed

Association of cetuximab with adverse pulmonary events in cancer patients: a comprehensive review

Jeffrey B Hoag, Aimel Azizi, Timothy J Doherty, Jason Lu, Rudolph E Willis and Mark E Lund
Journal of experimental & clinical cancer research, v 28(1), pp 113-113
14 Aug 2009
DOI: https://doi.org/10.1186/1756-9966-28-113
PMID: 19682368
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1186/1756-9966-28-113View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

Compounds derived from biologic sources, or biologicals, are increasingly utilized as therapeutic agents in malignancy. Development of anti-cancer targeted therapies from biologics is increasingly being utilized. Cetuximab, a chimeric monoclonal antibody, is one such anti-cancer targeted therapeutic that has shown efficacy in quelling the rate of patient decline in colorectal, head/neck, and non-small cell lung cancer. However, due to the relatively recent addition of biologic compounds to the therapeutic arsenal, information related to adverse reactions is less well known than those seen in traditional chemotherapeutics. Dermatologic reactions have been demonstrated as the most frequent side effect cited during cetuximab therapy for malignancy; however, other effects may lead to greater morbidity. In general, pulmonary complications of therapeutics can lead to significant morbidity and mortality. The purpose of this review is to compile the various pulmonary side effects seen in patients treated with cetuximab for various malignancies, and to compare the incidence of these adverse reactions to standard therapies.

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30 citations in Web of Science
41 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Web of Science research areas
Oncology
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