Journal article
Association of maternal birth weight and maternal preterm birth with subsequent risk for adverse reproductive outcomes: The Women's Health Initiative
Early human development, v 184, 105839
01 Sep 2023
PMID: 37549575
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Advancements in medical technology and pharmacologic interventions have drastically improved survival of infants born preterm and low birth weight, but knowledge regarding the long-term health impacts of these individuals is limited and inconsistent.
To investigate whether an individual's birthweight or history of being born preterm increases the risk of an adverse reproductive outcome.
Nested case-control study within the Women's Health Initiative.
79,934 individuals who self-reported their personal birthweight category and/or preterm birth status.
Self-reported pregnancy outcomes: subfertility, miscarriage, stillbirth, preeclampsia, gestational diabetes, gestational hypertension, preterm birth, low birthweight infant, high birthweight infant. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR).
After adjustments, individuals reporting their birthweight <6lbs. were 20 % more likely to have a stillbirth or 70 % more likely to have a low birthweight infant and were less likely to have a full-term birth or high birthweight infant during their pregnancy. Individuals reporting a birthweight ≥10 lbs. were more likely to have a high birthweight infant (OR 3.49, 95 % CI 2.73–4.39) and less likely to have a low birthweight infant (OR 0.64, 95 % CI 0.47–0.82). Individuals born preterm were at increased risk for infertility, miscarriage, preeclampsia, gestational diabetes, and delivering a preterm or low birthweight infant.
As more individuals born preterm and/or low birthweight survive to adulthood, the incidence and prevalence of poor reproductive outcomes may increase. Women born at extremes of birthweight and prematurity may need to be monitored more closely during their own pregnancies.
•Individuals born weighing <6 lbs. were more likely to have a stillbirth or a low birthweight infant•Individuals born weighing <6 lbs. were less likely to have a full-term birth or a high birthweight infant•Those born weighing ≥10 lbs. were more likely to have a high birthweight infant, less likely to have a low birthweight infant•Those born preterm were at increased risk for infertility, miscarriage, preeclampsia, preterm birth, or gestational diabetes•No significant associations between a woman’s birthweight or preterm birth status and ectopic pregnancy
Metrics
Details
- Title
- Association of maternal birth weight and maternal preterm birth with subsequent risk for adverse reproductive outcomes: The Women's Health Initiative
- Creators
- Christian Daniele - University of Massachusetts AmherstLeslie V. Farland - University of ArizonaKi Park - University of FloridaPeter F. Schnatz - Drexel UniversityAladdin H. Shadyab - Human Longevity (United States)Marcia L. Stefanick - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, 1265 Welch Road, Room X308, Stanford, CA 94305, United States of AmericaJean Wactawski-Wende - University at Buffalo, State University of New YorkRobert A. Wild - University of Oklahoma Health Sciences CenterCassandra N. Spracklen - University of Massachusetts Amherst
- Publication Details
- Early human development, v 184, 105839
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Drexel University
- Web of Science ID
- WOS:001054400900001
- Scopus ID
- 2-s2.0-85169547542
- Other Identifier
- 991021861277904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics