Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Association of multiple metabolic and cardiovascular markers with the risk of cognitive decline and mortality in adults with Alzheimer’s disease and AD-related dementia or cognitive decline: a prospective cohort study
Frontiers in aging neuroscience, v 16
01 Apr 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and objectives
There is a scarcity of data stemming from large-scale epidemiological longitudinal studies focusing on potentially preventable and controllable risk factors for Alzheimer’s disease (AD) and AD-related dementia (ADRD). This study aimed to examine the effect of multiple metabolic factors and cardiovascular disorders on the risk of cognitive decline and AD/ADRD.
Methods
We analyzed a cohort of 6,440 participants aged 45–84 years at baseline. Multiple metabolic and cardiovascular disorder factors included the five components of the metabolic syndrome [waist circumference, high blood pressure (HBP), elevated glucose and triglyceride (TG) concentrations, and reduced high-density lipoprotein cholesterol (HDL-C) concentrations], C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), factor VIII, D-dimer, and homocysteine concentrations, carotid intimal-medial thickness (CIMT), and urine albumin-to-creatinine ratio (ACR). Cognitive decline was defined using the Cognitive Abilities Screening Instrument (CASI) score, and AD/ADRD cases were classified using clinical diagnoses.
Results
Over an average follow-up period of 13 years, HBP and elevated glucose, CRP, homocysteine, IL-6, and ACR concentrations were significantly associated with the risk of mortality in the individuals with incident AD/ADRD or cognitive decline. Elevated D-dimer and homocysteine concentrations, as well as elevated ACR were significantly associated with incident AD/ADRD. Elevated homocysteine and ACR were significantly associated with cognitive decline. A dose–response association was observed, indicating that an increased number of exposures to multiple risk factors corresponded to a higher risk of mortality in individuals with cognitive decline or with AD/ADRD.
Conclusion
Findings from our study reaffirm the significance of preventable and controllable factors, including HBP, hyperglycemia, elevated CRP, D-dimer, and homocysteine concentrations, as well as, ACR, as potential risk factors for cognitive decline and AD/ADRD.
Metrics
Details
- Title
- Association of multiple metabolic and cardiovascular markers with the risk of cognitive decline and mortality in adults with Alzheimer’s disease and AD-related dementia or cognitive decline: a prospective cohort study
- Creators
- Longjian Liu - Drexel University, Epidemiology and BiostatisticsEdward J. Gracely - Drexel University, Epidemiology and BiostatisticsXiaopeng Zhao - University of Tennessee at KnoxvilleGediminas P. Gliebus - Drexel University, NeurologyNathalie S. May - Drexel University, College of MedicineStella L. Volpe - Virginia TechJingyi Shi - Mississippi State UniversityRose Ann DiMaria-Ghalili - Drexel University, Nutrition SciencesHoward J. Eisen - Thomas Jefferson University Hospital
- Publication Details
- Frontiers in aging neuroscience, v 16
- Publisher
- Frontiers Media S.A
- Grant note
- The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was partially supported by a grant from the National Institute on Aging (NIA, #1R21AG082210-01) and a grant from the Drexel University Areas of Research Excellence—Cell2Society Aging Research Network (#284060). This study was prepared using de-identified data from the Multi-Ethnic Study of Atherosclerosis (MESA) Research Materials obtained from the National Heart, Lung, and Blood Institute (NHLBI) Biologic Specimen and Data Repository Information Coordinating Center. This study does not necessarily reflect the opinions or views of the MESA or the NHLBI.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Epidemiology and Biostatistics; Neurology; College of Nursing and Health Professions
- Web of Science ID
- WOS:001203135700001
- Scopus ID
- 2-s2.0-85190514140
- Other Identifier
- 991021866483204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Neurosciences