Journal article
Association of plasma levels of soluble receptor for advanced glycation end products and risk of kidney disease: the Atherosclerosis Risk in Communities study
Nephrology, dialysis, transplantation, v 30(1), pp 77-83
01 Jan 2015
PMID: 25147225
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background. Advanced glycation end products and their cell-bound receptors are thought to mediate the adverse effects of vascular disease through oxidative stress, inflammation and endothelial dysfunction. We examined the association between the soluble form of receptor for advanced glycation end products (sRAGE) and kidney disease.
Methods. In this case-cohort study nested within the Atherosclerosis Risk in Communities (ARIC) study, baseline sRAGE levels were measured in a cohort random sample of participants without kidney disease (n = 1218), and among participants who developed incident chronic kidney disease (CKD) [estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m(2) and >= 25% eGFR decline, n = 151] and end-stage renal disease (ESRD) [entry in the US Renal Data System (USRDS) registry, n = 152].
Results. Baseline sRAGE levels were inversely related to baseline eGFR (r = -0.13). After adjusting for age, sex and race, one interquartile range higher log(10)-transformed sRAGE was associated with development of CKD [odds ratio: 1.39; 95% confidence interval (95% CI) 1.06-1.83; P = 0.02] and ESRD (hazard ratio: 1.97; 95% CI 1.47-2.64; P < 0.001). These associations were not significant after eGFR adjustment.
Conclusions. High sRAGE levels are associated with incident CKD and ESRD risk, but not after adjustment for kidney function at baseline. Future studies are needed to investigate specific mechanisms underlying the association of sRAGE with kidney disease risk.
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Details
- Title
- Association of plasma levels of soluble receptor for advanced glycation end products and risk of kidney disease: the Atherosclerosis Risk in Communities study
- Creators
- Casey M. Rebholz - Bloomberg (United States)Brad C. Astor - University of Wisconsin–MadisonMorgan E. Grams - Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USAMarc K. Halushka - Johns Hopkins MedicineMariana Lazo - Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USARon C. Hoogeveen - Baylor College of MedicineChristie M. Ballantyne - Baylor College of MedicineJosef Coresh - Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USAElizabeth Selvin - Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA
- Publication Details
- Nephrology, dialysis, transplantation, v 30(1), pp 77-83
- Publisher
- Oxford Univ Press
- Number of pages
- 8
- Grant note
- T32HL007024 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01DK076770 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) HHSN268201100005C; HHSN 268201100006C; HHSN268201100007C; HHSN2682011000 08C; HHSN268201100009C; HHSN268201100010C; HHSN 268201100011C; HHSN268201100012C; T32HL007024 / National Heart, Lung and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) American Heart Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000351659800017
- Scopus ID
- 2-s2.0-84922422557
- Other Identifier
- 991020550500104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Transplantation
- Urology & Nephrology