Journal article
Association of psychosocial factors with leukocyte telomere length among African Americans in the Jackson Heart Study
Stress and health, v 35(2)
01 Apr 2019
PMID: 30407711
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Leukocyte telomere length (LTL) is a biomarker of cellular aging. African Americans report more stress than other groups; however, the association of psychosocial stressors with biological aging among African Americans remains unclear. The current study evaluated the association of psychosocial factors (negative affect and stressors) with LTL in a large sample of African American men and women (n = 2,516) from the Jackson Heart Study. Using multivariable linear regression, we examined the sex-specific associations of psychosocial factors (cynical distrust, anger in and out, depressive symptoms, negative affect summary scores, global stress, weekly stress, major life events, and stress summary scores) with LTL. Model 1 adjusted for demographics and education. Model 2 adjusted for model 1, smoking, alcohol intake, physical activity, diabetes, hypertension, and high-sensitivity C-reactive protein. Among women, high (vs. low) cynical distrust was associated with shorter mean LTL in model 1 (b = -0.12; p = 0.039). Additionally, high (vs. low) anger out and expressed negative affect summary scores were associated with shorter LTL among women after full adjustment (b = -0.13; p = 0.011; b = -0.12, p = 0.031, respectively). High levels of cynical distrust, anger out, and negative affect summary scores may be risk factors for shorter LTL, particularly among African-American women.
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Details
- Title
- Association of psychosocial factors with leukocyte telomere length among African Americans in the Jackson Heart Study
- Creators
- Christina D. Jordan - University of Mississippi Medical CenterLaShaunta M. Glover - University of North Carolina at Chapel HillYan Gao - University of Mississippi Medical CenterSolomon K. Musani - University of Mississippi Medical CenterStanford Mwasongwe - Jackson State UniversityJames G. Wilson - Univ Mississippi, Med Ctr, Sch Med, Jackson, MS 39216 USAAlex Reiner - Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USAAna Diez-Roux - Drexel UniversityMario Sims - University of Mississippi Medical Center
- Publication Details
- Stress and health, v 35(2)
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) HHSN268201800010I; HHSN268201800011I; HHSN268201800012I / University of Mississippi Medical Center HHSN268201800013I / Jackson Heart Study (JHS), Jackson State University National Institute for Minority Health and Health Disparities (NIMHD); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) HHSN268201800014I / Tougaloo College HHSN268201800015I / Mississippi State Department of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000466030900003
- Scopus ID
- 2-s2.0-85058963919
- Other Identifier
- 991019168363404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry
- Psychology
- Psychology, Applied