Journal article
Association of subjective social status with epigenetic aging among Black and White women
Psychoneuroendocrinology, v 141, 105748
01 Jul 2022
PMID: 35397259
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Subjective social status (SSS), an individual’s assessment of their own social status in relation to others, is associated with health and mortality independently of objective SES; however, no studies have tested whether SSS influences epigenetic aging. The current study examines if SSS is associated with epigenetic age acceleration in both Black and White women, independently of objective SES measured during both childhood and adulthood.
For 9- and 10-year-old Black and White girls, parental education and annual household income was obtained. At ages 39–42, 361 participants (175 Black, 186 White) reported their current education, household income, and SSS, and provided saliva to assess age acceleration using the GrimAge epigenetic clock. Linear regression estimated the association of SSS with epigenetic age acceleration, controlling for objective SES (current education, current income, parents’ education, income during childhood), smoking, and counts of cell types.
When all objective SES variables were included in the model, SSS remained significantly associated with epigenetic age acceleration, b = − 0.31, p = .003, ß = − 0.15. Black women had significantly greater age acceleration than White women, (t(359) = 5.20, p > .001, d = 0.55) but race did not moderate the association between SSS and epigenetic age acceleration.
Women who rated themselves lower in SSS had greater epigenetic age acceleration, regardless of income and education. There was no difference by race for this association.
• Women lower in subjective social status had greater epigenetic age acceleration.
• Accelerated epigenetic aging may link subjective social status and health.
• Race did not moderate the relationship between social status and epigenetic age.
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Details
- Title
- Association of subjective social status with epigenetic aging among Black and White women
- Creators
- Elissa J. Hamlat - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, USANancy E. Adler - University of California, San FranciscoBarbara Laraia - University of California, BerkeleyAgus Surachman - Drexel University, Epidemiology and BiostatisticsAke T. Lu - Department of Human Genetics, University of California, Los Angeles, USAJoshua Zhang - Department of Human Genetics, University of California, Los Angeles, USASteve Horvath - Department of Human Genetics, University of California, Los Angeles, USAElissa S. Epel - University of California, San Francisco
- Publication Details
- Psychoneuroendocrinology, v 141, 105748
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Dana and David Dornsife School of Public Health; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000806353300003
- Scopus ID
- 2-s2.0-85127522801
- Other Identifier
- 991021893415204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Endocrinology & Metabolism
- Neurosciences
- Psychiatry