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Journal article
Association of type 2 diabetes mellitus with dementia-related and non-dementia-related mortality among postmenopausal women: A secondary competing risks analysis of the women's health initiative
Alzheimer's & dementia, v 20(1), pp 234-242
Jan 2024
PMID: 37563765
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
INTRODUCTION
Alzheimer's disease (AD) and AD‐related dementias (ADRD) are leading causes of death among older adults in the United States. Efforts to understand risk factors for prevention are needed. METHODS Participants ( n = 146,166) enrolled in the Women's Health Initiative without AD at baseline were included. Diabetes status was ascertained from self‐reported questionnaires and deaths attributed to AD/ADRD from hospital, autopsy, and death records. Competing risk regression models were used to estimate the cause‐specific hazard ratios (HRs) and 95% confidence intervals (CIs) for the prospective association of type 2 diabetes mellitus (T2DM) with AD/ADRD and non‐AD/ADRD mortality.
RESULTS
There were 29,393 treated T2DM cases and 8628 AD/ADRD deaths during 21.6 (14.0–23.5) median (IQR) years of follow‐up. Fully adjusted HRs (95% CIs) of the association with T2DM were 2.94 (2.76–3.12) for AD/ADRD and 2.65 (2.60–2.71) for the competing risk of non‐AD/ADRD mortality.
DISCUSSION
T2DM is associated with AD/ADRD and non‐AD/ADRD mortality. Highlights Type 2 diabetes mellitus is more strongly associated with Alzheimer's disease (AD)/AD and related dementias (ADRD) mortality compared to the competing risk of non‐AD/ADRD mortality among postmenopausal women. This relationship was consistent for AD and ADRD, respectively. This association is strongest among participants without obesity or hypertension and with younger age at baseline, higher diet quality, higher physical activity, higher alcohol consumption, and older age at the time of diagnosis of type 2 diabetes mellitus.
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Details
- Title
- Association of type 2 diabetes mellitus with dementia-related and non-dementia-related mortality among postmenopausal women: A secondary competing risks analysis of the women's health initiative
- Creators
- Tyler J. Titcomb - University of IowaPhyllis Richey - University of Tennessee Health Science CenterRamon Casanova - Wake Forest UniversityLawrence S. Phillips - Atlanta VA Medical CenterSimin Liu - Brown UniversityShama D. Karanth - University of FloridaNazmus Saquib - Sulaiman Al Rajhi CollegesTomas Nuño - University of ArizonaJoAnn E. Manson - Brigham and Women's HospitalAladdin H. Shadyab - Human Longevity (United States)Longjian Liu - Drexel UniversityTerry L. Wahls - University of IowaLinda G. Snetselaar - University of IowaRobert B. Wallace - University of IowaWei Bao - University of Science and Technology of China
- Publication Details
- Alzheimer's & dementia, v 20(1), pp 234-242
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- P30 ES005605 / NIEHS NIH HHS 75N92021D00002 / NHLBI NIH HHS R21 HD091458 / NICHD NIH HHS T32 DK112751 / NIDDK NIH HHS RF1 AG074345 / NIA NIH HHS RF1 AG079149 / NIA NIH HHS 75N92021D00003 / WHI NIH HHS 75N92021D00001 / NHLBI NIH HHS 75N92021D00005 / WHI NIH HHS 75N92021D00004 / WHI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:001045318700001
- Scopus ID
- 2-s2.0-85167598152
- Other Identifier
- 991020924040904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology