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Journal article
Associations Between Laryngeal and Cough Dysfunction in Motor Neuron Disease with Bulbar Involvement
Dysphagia, v 29(6), pp 637-646
01 Dec 2014
PMID: 25037590
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
True vocal fold (TVF) dysfunction may lead to cough ineffectiveness. In individuals with motor neuron disease (MND), cough impairment in the context of dysphagia increases risk for aspiration and respiratory failure. This study characterizes differences and associations between TVF kinematics and airflow during cough in individuals with bulbar MND. Sequential glottal angles associated with TVF movements during volitional cough were analyzed from laryngeal video endoscopy examinations of adults with bulbar MND (n = 12) and healthy controls (n = 12) and compared with simultaneously collected cough-related airflow measures. Significant group differences were observed with airflow and TVF measures: volume acceleration (p a parts per thousand currency sign 0.001) and post-compression abduction TVF angle average velocity (p = 0.002) were lower and expiratory phase rise time (p = 0.001) was higher in the MND group. Reductions in maximum TVF angle during post-compression abduction in the MND group approached significance (p = 0.09). All subjects demonstrated complete TVF and supraglottic closure during the compression phase of cough, except for incomplete supraglottic closure in 2/12 MND participants. A strong positive relationship between post-compression maximum TVF abduction angle and peak expiratory cough flow was observed in the MND group, though it was not statistically significant (r = 0.55; p = 0.098). Reductions in the speed and extent of TVF abduction are seen during the expulsion phase of cough in individuals with MND. This may contribute to cough impairment and morbidity.
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Details
- Title
- Associations Between Laryngeal and Cough Dysfunction in Motor Neuron Disease with Bulbar Involvement
- Creators
- Joshua O. Benditt - University of Washington Medical CenterAlbert L. Merati - University of Washington Medical CenterRobert M. Miller - University of WashingtonCara E. Stepp - Boston UniversityLouis Boitano - University of Washington Medical CenterAmanda Hu - Drexel UniversityMarcia A. Ciol - University of WashingtonKathryn M. Yorkston - University of Washington
- Publication Details
- Dysphagia, v 29(6), pp 637-646
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- F31DC011689 / NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD) F31 DC011689 / NIH/NIDCD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD) Walter C. and Anita C. Stolov Research Fund
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000345624500001
- Scopus ID
- 2-s2.0-84926609401
- Other Identifier
- 991019168906004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Otorhinolaryngology