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Journal article
Associations between aflatoxin B-1-albumin adduct levels with metabolic conditions in Guatemala: A cross-sectional study
Health science reports, v 5(1), pe495
01 Jan 2022
PMID: 35229049
Abstract
Background and Aims Metabolic conditions such as obesity, type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD) are highly prevalent in Guatemala and increase the risk for a number of disorders, including hepatocellular carcinoma (HCC). Aflatoxin B-1 (AFB(1)) levels are also notably elevated in the population and are known to be associated with HCC risk. Whether AFB(1) also contributes to the high prevalence of the metabolic disorders has not been previously examined. Therefore, the purpose of this study was to assess the association between AFB(1) and the metabolic conditions. Methods Four-hundred twenty-three individuals were included in the study, in which AFB(1)-albumin adduct levels were measured in sera. Metabolic conditions included diabetes, obesity, central obesity, metabolic syndrome, and NAFLD. Crude and adjusted prevalence odds ratios (PORs) and 95% confidence intervals (95% CI) were estimated for the associations between the metabolic conditions and AFB(1)-albumin adduct levels categorized into quartiles. Results The study found a significant association between AFB(1)-albumin adduct levels and diabetes (Q4 vs Q1 POR = 3.74, 95%CI: 1.71-8.19; P-trend .003). No associations were observed between AFB(1)-albumin adduct levels and the other conditions. Conclusions As diabetes is the metabolic condition most consistently linked to HCC, the possible association between AFB(1) exposure and diabetes may be of public health importance. Further studies are warranted to replicate the findings and examine potential mechanisms.
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Details
- Title
- Associations between aflatoxin B-1-albumin adduct levels with metabolic conditions in Guatemala: A cross-sectional study
- Creators
- Christian S. Alvarez - National Cancer InstituteAlvaro Rivera-Andrade - Inst Nutr Cent Amer & Panama, INCAP Res Ctr Prevent Chron Dis, Guatemala City, GuatemalaMaria F. Kroker-Lobos - Inst Nutr Cent Amer & Panama, INCAP Res Ctr Prevent Chron Dis, Guatemala City, GuatemalaAndrea A. Florio - Harvard UniversityJoshua W. Smith - Johns Hopkins UniversityPatricia A. Egner - Johns Hopkins UniversityNeal D. Freedman - National Cancer InstituteMariana Lazo - Drexel UniversityEliseo Guallar - Johns Hopkins UniversityMichael Dean - National Cancer InstituteBarry Graubard - National Cancer InstituteManuel Ramirez-Zea - Inst Nutr Cent Amer & Panama, INCAP Res Ctr Prevent Chron Dis, Guatemala City, GuatemalaKatherine A. McGlynn - National Cancer InstituteJohn D. Groopman - Johns Hopkins University
- Publication Details
- Health science reports, v 5(1), pe495
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- T32ES007141 / Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P30CA006973-52S3; 2T32DK007703-26 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000751732500028
- Scopus ID
- 2-s2.0-85124379083
- Other Identifier
- 991020550342904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health