Journal article
Associations between high ambient temperatures and asthma exacerbation among children in Philadelphia, PA: a time series analysis
Occupational and environmental medicine (London, England), v 79(5), pp 326-332
04 Mar 2022
PMID: 35246484
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ObjectivesHigh ambient temperatures may contribute to acute asthma exacerbation, a leading cause of morbidity in children. We quantified associations between hot-season ambient temperatures and asthma exacerbation in children ages 0–18 years in Philadelphia, PA.MethodsWe created a time series of daily counts of clinical encounters for asthma exacerbation at the Children’s Hospital of Philadelphia linked with daily meteorological data, June–August of 2011–2016. We estimated associations between mean daily temperature (up to a 5-day lag) and asthma exacerbation using generalised quasi-Poisson distributed models, adjusted for seasonal and long-term trends, day of the week, mean relative humidity,and US holiday. In secondary analyses, we ran models with adjustment for aeroallergens, air pollutants and respiratory virus counts. We quantified overall associations, and estimates stratified by encounter location (outpatient, emergency department, inpatient), sociodemographics and comorbidities.ResultsThe analysis included 7637 asthma exacerbation events. High mean daily temperatures that occurred 5 days before the index date were associated with higher rates of exacerbation (rate ratio (RR) comparing 33°C–13.1°C days: 1.37, 95% CI 1.04 to 1.82). Associations were most substantial for children ages 2 to <5 years and for Hispanic and non-Hispanic black children. Adjustment for air pollutants, aeroallergens and respiratory virus counts did not substantially change RR estimates.ConclusionsThis research contributes to evidence that ambient heat is associated with higher rates of asthma exacerbation in children. Further work is needed to explore the mechanisms underlying these associations.
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Details
- Title
- Associations between high ambient temperatures and asthma exacerbation among children in Philadelphia, PA: a time series analysis
- Creators
- Leah H Schinasi - Drexel UniversityChen C Kenyon - University of PennsylvaniaRebecca A Hubbard - University of PennsylvaniaYuzhe Zhao - Drexel UniversityMitchell Maltenfort - Children's Hospital of PhiladelphiaSteven J Melly - Drexel UniversityKari Moore - Drexel UniversityChristopher B Forrest - Children's Hospital of PhiladelphiaAna V Diez Roux - Drexel UniversityAnneclaire J de Roos - Drexel University
- Publication Details
- Occupational and environmental medicine (London, England), v 79(5), pp 326-332
- Publisher
- BMJ Publishing Group Ltd
- Grant note
- SAP #4100072543. / Pennsylvania Department of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Environmental and Occupational Health
- Web of Science ID
- WOS:000765862000001
- Scopus ID
- 2-s2.0-85128487352
- Other Identifier
- 991019167417604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health