Journal article
Associations between neighborhood built-environment characteristics and hepatic steatosis: The Multi-Ethnic Study of Atherosclerosis
Health & place, v 91, 103392
Jan 2025
PMID: 39644759
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To characterize the spatio-temporal association between features of the built environment and subclinical liver disease.
We used data from a large community-based population, the Multi-Ethnic Study of Atherosclerosis (2000–2002, N = 5542) with linked historical residential data that characterized past exposure to alcohol outlets (bars and liquor stores), healthy foods stores, and physical activity facilities (1990–2001). We examined whether and how past residential relate to hepatic steatosis (proxied by liver attenuation measured using computed tomography, with lower attenuation indicating higher hepatic steatosis). Hepatic steatosis is the most common.
We found significant associations between past residential exposure to neighborhood alcohol outlets, healthy food and physical activity resources, and hepatic steatosis. The spatial scale where the association between these features of the built environment and hepatic steatosis operate lies within 3 km (∼2 miles). The average association on liver attenuation per additional bar, liquor, healthy food store, and physical activity facility within a 2-mile buffer, were: −0.06 (95% CI -0.09, −0.03), −0.02 (95% CI -0.04, −0.009), 0.05 (95% CI 0.02, 0.07), 0.02 (95% CI 0.01, 0.04), respectively, in the preceding year of the measurement of hepatic steatosis. Furthermore, the association and spatial scale remains consistent ten years prior to the measurement of hepatic steatosis.
Our results suggest that modifying neighborhood environments (decreasing alcohol outlets and improving access to healthy food and physical activity) may represent an effective population-wide approach to reduce liver-related morbidity.
• The association between neighborhood features on subclinical liver disease (hepatic steatosis) is unknown.
• Exposure to residential environments with higher access to alcohol outlets, and reduces access to healthy food stores and physical activity facilities associated with more hepatic steatosis.
• Modifying these residential characteristics may represent an effective population-wide approach to prevent liver-related morbidity.
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Details
- Title
- Associations between neighborhood built-environment characteristics and hepatic steatosis: The Multi-Ethnic Study of Atherosclerosis
- Creators
- Mariana Lazo - Drexel University, Urban Health CollaborativeJingjing Li - Drexel University, Urban Health CollaborativeJana A. Hirsch - Drexel University, Urban Health CollaborativeKari A. Moore - Drexel University, Urban Health CollaborativeAmy H. Auchincloss - Drexel University, Urban Health CollaborativeLoni P. Tabb - Drexel University, Epidemiology and BiostatisticsTonatiuh Barrientos-Gutierrez - Instituto Nacional de Salud PúblicaJeanne M. Clark - Johns Hopkins UniversitySteven F. Solga - University of PennsylvaniaMatt J. Budoff - The Lundquist InstituteBrisa N. Sánchez - Drexel University, Urban Health Collaborative
- Publication Details
- Health & place, v 91, 103392
- Publisher
- Elsevier
- Number of pages
- 7
- Grants
- Grant note
- National Heart, Lung, and Blood Institute: 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169 National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (USA): R01 HL131610, R01 HL071759, R01DK136171 National Center for Advancing Translational Sciences (NCATS): UL1-TR-000040, UL1-TR-001079, UL1-TR-001420 National Institute of Aging: R01AG049970, R01AG049970-S1, R56AG049970 Commonwealth Universal Research Enhancement (C. U.R.E) program - Pennsylvania Department of Health: 4100072543 Urban Health Collaborative at Drexel UniversityBuilt Environment and Health Research Group at Columbia University This work was supported by the National Heart, Lung, and Blood Institute, and the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (USA) (grant numbers: R01 HL131610, R01 HL071759, and R01DK136171). The Multi-Ethnic Study of Atherosclerosis (MESA) was supported by contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences (NCATS). The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http:// www.mesa-nhlbi. org. This paper has been reviewed and approved by the MESA Publications and Presentations Committee. The Retail Environments for Cardiovascular Disease (RECVD) was supported by the National Institute of Aging (grants R01AG049970, R01AG049970-S1, R56AG049970), Commonwealth Universal Research Enhancement (C. U.R.E) program funded by the Pennsylvania Department of Health-2015 Formula award-SAP #4100072543, the Urban Health Collaborative at Drexel University, and the Built Environment and Health Research Group at Columbia University.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics; Community Health and Prevention
- Web of Science ID
- WOS:001376810000001
- Scopus ID
- 2-s2.0-85211068083
- Other Identifier
- 991021985204204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health