Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Associations betweenHelicobacter pyloriwith nonalcoholic fatty liver disease and other metabolic conditions in Guatemala
Helicobacter (Cambridge, Mass.), v 25(6)
01 Dec 2020
PMID: 33006810
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background Previous studies have suggested an association betweenHelicobacter pylori(H pylori) and nonalcoholic fatty liver disease (NAFLD). The aim of the current study was to examine the association in Guatemala, a region with elevated prevalences of bothH pyloriand NAFLD. Associations betweenH pyloriand other metabolic conditions were also examined, as were associations betweenH hepaticusandH bilisand the metabolic conditions. Materials & Methods The analysis included 424 participants from a cross-sectional study in Guatemala.H pyloriseropositivity was defined as positivity for >= 4 antigens. Seropositivities forH bilisandH hepaticuswere defined as positivity for >= 2 antigens. NAFLD was estimated using the Fatty Liver Index and the Hepatic Steatosis Index. Other conditions examined were obesity, central obesity, hypercholesterolemia, low HDL, diabetes and metabolic syndrome (MetSyn). Prevalence odds ratios (POR) and 95% confidence intervals (CIs) were estimated. Results No overall associations betweenH pylori,H hepaticus, orH bilisand NAFLD or related metabolic conditions were found. Seropositivity forH pyloriantigens CagA and VacA andH hepaticusantigen HH0713 was each significantly associated with NAFLD, however. In addition, associations were observed between theH pyloriantigens HyuA, HP1564, and UreA and specified metabolic conditions. Conclusions While no overall associations betweenH pyloriorHelicobacterspecies with NAFLD or related conditions were observed, some selectedHelicobacterspp. antigens were associated with NAFLD. Further research is warranted to examine whetherH. species are associated with any metabolic condition.
Metrics
Details
- Title
- Associations betweenHelicobacter pyloriwith nonalcoholic fatty liver disease and other metabolic conditions in Guatemala
- Creators
- Christian S. Alvarez - National Cancer InstituteAndrea A. Florio - National Cancer InstituteJulia Butt - German Cancer Research CenterAlvaro Rivera-Andrade - Institute of Nutrition of Central America and PanamaMaria F. Kroker-Lobos - Institute of Nutrition of Central America and PanamaTim Waterboer - German Cancer Research CenterMaria Constanza Camargo - College Station Medical CenterNeal D. Freedman - National Cancer InstituteBarry I. Graubard - National Cancer InstituteMariana Lazo - Drexel UniversityEliseo Guallar - Johns Hopkins UniversityJohn D. Groopman - Johns Hopkins UniversityManuel Ramirez-Zea - Institute of Nutrition of Central America and PanamaKatherine A. McGlynn - National Cancer Institute
- Publication Details
- Helicobacter (Cambridge, Mass.), v 25(6)
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- P30CA006973-52S3 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Intramural Research Program, National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000574195100001
- Scopus ID
- 2-s2.0-85091753292
- Other Identifier
- 991020550338304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology
- Microbiology