Associations of Insulin Resistance and Glycemia With Liver Enzymes in Hispanic/Latino Youths: Results From the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

Christina M Parrinello; Bryan J Rudolph; Mariana Lazo; Linda C Gallo; Bharat Thyagarajan; Scott J Cotler; Qibin Qi; Tossaporn Seeherunvong; Denise C Vidot; Howard D Strickler; Robert C Kaplan; Carmen R Isasi

doi:10.1097/MCG.0000000000000946

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Associations of Insulin Resistance and Glycemia With Liver Enzymes in Hispanic/Latino Youths: Results From the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

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Associations of Insulin Resistance and Glycemia With Liver Enzymes in Hispanic/Latino Youths: Results From the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

Christina M Parrinello, Bryan J Rudolph, Mariana Lazo, Linda C Gallo, Bharat Thyagarajan, Scott J Cotler, Qibin Qi, Tossaporn Seeherunvong, Denise C Vidot, Howard D Strickler, …

Journal of clinical gastroenterology, v 53(2), pp e46-e53

Feb 2019

DOI: https://doi.org/10.1097/MCG.0000000000000946

PMID: 29099463

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Abstract

Adolescent

Alanine Transaminase - metabolism

Aspartate Aminotransferases - metabolism

Blood Glucose - metabolism

Child

Cross-Sectional Studies

Female

gamma-Glutamyltransferase - metabolism

Hispanic Americans

Humans

Insulin Resistance

Liver - enzymology

Male

Non-alcoholic Fatty Liver Disease - epidemiology

Pediatric Obesity - epidemiology

Associations of insulin resistance and hyperglycemia with a panel of liver enzymes have not been well studied in a young, heterogenous Hispanic/Latino population. We aimed to assess the associations of insulin resistance and glycemia with nonalcoholic fatty liver disease (NAFLD), as measured by liver enzymes and the pediatric NAFLD fibrosis index (PNFI), and whether these associations are modified by body mass index and mediated by inflammation or endothelial dysfunction. We conducted a cross-sectional study of 1317 boys and girls aged 8 to 16 years from the Hispanic Community Children's Health Study/Study of Latino Youth. We used Poisson regression to assess the associations of fasting glucose, hemoglobin A1c, and homeostasis model assessment of insulin resistance (HOMA-IR) with elevated alanine aminotransferase (ALT) (>25 U/L in boys, >22 U/L in girls), aspartate aminotransferase (AST) (≥37 U/L), gamma-glutamyl transpeptidase (GGT) (≥17 U/L), and PNFI (≥9; a function of age, waist circumference, and triglyceride level). HOMA-IR was associated with elevated ALT, AST, GGT, and PNFI [prevalence ratios (95% confidence intervals) for each 1-unit increase in the natural log of HOMA-IR: 1.99 (1.40-2.81), 2.15 (1.12-4.12), 1.70 (1.26-2.30), and 1.98 (1.43-2.74), respectively]. Associations were observed in overweight/obese children, but not in normal weight children (P-interaction=0.04 for AST and P-interaction=0.07 for GGT). After further adjustment for adiponectin, high-sensitivity C-reactive protein, e-selectin, and PAI-1, associations of HOMA-IR with liver enzymes and PNFI were attenuated, but remained statistically significant for AST and PNFI. Insulin resistance was associated with NAFLD in overweight/obese Hispanic/Latino youth, and this association may be partially mediated by inflammation and endothelial dysfunction.

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Title: Associations of Insulin Resistance and Glycemia With Liver Enzymes in Hispanic/Latino Youths: Results From the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)
Creators: Christina M Parrinello - Department of Epidemiology and Population Health
Bryan J Rudolph - Albert Einstein College of Medicine
Mariana Lazo - Johns Hopkins School of Medicine and the Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, MD.
Linda C Gallo - San Diego State University
Bharat Thyagarajan - University of Minnesota
Scott J Cotler - Loyola University Chicago
Qibin Qi - Department of Epidemiology and Population Health
Tossaporn Seeherunvong - University of Miami
Denise C Vidot - University of Miami
Howard D Strickler - Department of Epidemiology and Population Health
Robert C Kaplan - Department of Epidemiology and Population Health
Carmen R Isasi - Department of Epidemiology and Population Health
Publication Details: Journal of clinical gastroenterology, v 53(2), pp e46-e53
Publisher: Lippincott
Grant note: N01HC65235 / NHLBI NIH HHS R01 MD011389 / NIMHD NIH HHS UL1 TR001073 / NCATS NIH HHS N01HC65234 / NHLBI NIH HHS K01 HL129892 / NHLBI NIH HHS R01 HL136266 / NHLBI NIH HHS N01HC65237 / NHLBI NIH HHS P30 DK041296 / NIDDK NIH HHS P30 DK111022 / NIDDK NIH HHS N01HC65233 / NHLBI NIH HHS R01 HL102130 / NHLBI NIH HHS N01HC65236 / NHLBI NIH HHS UL1 TR002556 / NCATS NIH HHS
Resource Type: Journal article
Language: English
Academic Unit: Urban Health Collaborative
Web of Science ID: WOS:000458415900001
Scopus ID: 2-s2.0-85059795844
Other Identifier: 991020550492104721

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Collaboration types: Domestic collaboration
Web of Science research areas: Gastroenterology & Hepatology

Associations of Insulin Resistance and Glycemia With Liver Enzymes in Hispanic/Latino Youths: Results From the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

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Abstract

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UN Sustainable Development Goals (SDGs)

InCites Highlights

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